Quorum sensing systems as a new target to prevent biofilm‐related oral diseases

Objective The present study summarizes the current knowledge on the role of bacterial extracellular signaling systems, known as quorum sensing (QS), in oral biofilm formation, and on the possibility of blocking these microbial communication systems as a potential approach to prevent and treat oral i...

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Published in:Oral diseases 2022-03, Vol.28 (2), p.307-313
Main Authors: Muras, Andrea, Mallo, Natalia, Otero‐Casal, Paz, Pose‐Rodríguez, José M., Otero, Ana
Format: Article
Language:English
Subjects:
Bacteria - genetics
Biofilms
Cell interactions
Chemical communication
Communication
Communications systems
Dental caries
Ecosystem
Gene expression
Gum disease
Infectious diseases
Literature reviews
Oral cavity
periodontal disease
Porphyromonas
quorum quenching
Quorum sensing
Quorum Sensing - physiology
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Summary:Objective The present study summarizes the current knowledge on the role of bacterial extracellular signaling systems, known as quorum sensing (QS), in oral biofilm formation, and on the possibility of blocking these microbial communication systems as a potential approach to prevent and treat oral infectious diseases. Methods A detailed literature review of the current knowledge of QS in the oral cavity was performed, using the databases MEDLINE (through PubMed) and Web of Science. Results Accumulating direct and indirect evidence indicates an important role of QS molecules in the oral microbial ecosystem. Conclusions The mechanisms regulating gene expression through bacterial communication systems constitute a promising target to control oral biofilm formation. Although cell‐to‐cell communication is pivotal for biofilm formation of many pathogenic bacteria, knowledge concerning microbial interactions and signaling processes within multispecies biofilms in the oral cavity is still limited.
ISSN:1354-523X
1601-0825
DOI:10.1111/odi.13689