Evaluation of the Erythrocyte Membrane in Head and Neck Cancer Patients

Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous and complex disease, both from a clinical and molecular point of view. The prolonged use of alcohol and tobacco, along with the release of tumor secretions can modulate blood cells, such as erythrocytes. Here, this study was conducted...

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Bibliographic Details
Published in:The Journal of membrane biology 2020-12, Vol.253 (6), p.617-629
Main Authors: De Souza Gonçalves, Bruno, Toledo, Marina Marques, Colodette, Natalie Mounteer, Chaves, Aline Lauda Freitas, Muniz, Luciana Vieira, Ribeiro, Rosy Iara Maciel De A., Dos Santos, Hélio Batista, Cortes, Vanessa F., Soares, João Marcos Arantes, Barbosa, Leandro A., de Lima Santos, Hérica
Format: Article
Language:English
Subjects:
Biochemistry
Biomarkers
Biomedical and Life Sciences
Cancer
Cholesterol
Erythrocytes
Fragility
Head & neck cancer
Human Physiology
Lecithin
Life Sciences
Lipid peroxidation
Lipids
Membranes
Na+/K+-exchanging ATPase
Phosphatidylcholine
Phosphatidylethanolamine
Phospholipids
Secretions
Squamous cell carcinoma
Tobacco
Tumors
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Summary:Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous and complex disease, both from a clinical and molecular point of view. The prolonged use of alcohol and tobacco, along with the release of tumor secretions can modulate blood cells, such as erythrocytes. Here, this study was conducted with 24 patients diagnosed with HNSCC and an equal number of healthy individuals are matched by age and gender. The levels of lipid peroxidation were measured using the individual plasma, while for lipid concentrations, identification and quantification Na, K-ATPase activity and osmotic fragility, the red blood cell concentrate were used. The release of TBARS was significantly higher in patients with HNSCC. The lipid profile assays demonstrated a rearrangement of the erythrocyte membrane due to a decrease in total phospholipids and phosphatidylethanolamine followed by an increase in total cholesterol and phosphatidylcholine. Na, K-ATPase activity also increased. Erythrocytes were more fragile in patients with HNSCC than in health individuals. Therefore, the membrane of erythrocytes were rearranged and Na, K-ATPase function altered in the HNSCC patients. Our findings suggests that the alcohol, tobacco and tumor secretion modulate in a specific manner that the erythrocytes membranes of these patients making this system a potential tool for HNSCC biomarker of tumor progression. Graphic Abstract
ISSN:0022-2631
1432-1424
DOI:10.1007/s00232-020-00147-w