Dietary microRNAs and cancer: A new therapeutic approach?

• Published in: Seminars in cancer biology 2021-08, Vol.73, p.19-29
• Main Authors: Dávalos, Alberto, Pinilla, Lucía, López de las Hazas, María-Carmen, Pinto-Hernández, Paola, Barbé, Ferran, Iglesias-Gutiérrez, Eduardo, de Gonzalo-Calvo, David
• Format: Article
• Language: English
• Subjects: Animals; Cancer; Diet; Dietary microRNAs; Humans; MicroRNAs; Neoplasms; Plant microRNAs; Plants
• ISSN: 1044-579X; 1096-3650
• DOI: 10.1016/j.semcancer.2020.10.006

Cancer is one of the leading causes of premature death and constitutes a challenge for both low- and high-income societies. Previous evidence supports a close association between modifiable risk factors, including dietary habits, and cancer risk. Investigation of molecular mechanisms that mediate the pro-oncogenic and anti-oncogenic effects of diet is therefore fundamental. MicroRNAs (miRNAs) have received much attention in the past few decades as crucial molecular elements of human physiology and disease. Aberrant expression patterns of these small noncoding transcripts have been observed in a wide array of cancers. Interestingly, human miRNAs not only can be modulated by bioactive dietary components, but it has also been proposed that diet-derived miRNAs may contribute to the pool of human miRNAs. Results from independent groups have suggested that these exogenous miRNAs may be functional in organisms. These findings open the door to novel and innovative approaches to cancer therapy. Here, we provide an overview of the biology of miRNAs, with a special focus on plant-derived dietary miRNAs, summarize recent findings in the field of cancer, address the possible applications to clinical practice and discuss obstacles and challenges in the field.