Assessment of SE-MRE-derived shear stiffness at 3.0 Tesla for solid liver tumors characterization

Objectives To evaluate the feasibility and diagnostic value of using a 2D spin-echo MR elastography (SE-MRE) sequence at 3.0 Tesla for solid focal liver lesions (FLL) characterization. Methods This prospective study included 55 patients with solid FLL (size > 20 mm), who underwent liver SE-MRE at...

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Bibliographic Details
Published in:Abdominal imaging 2021-05, Vol.46 (5), p.1904-1911
Main Authors: Dominguez, Andrés, Fino, Daniel, Spina, Juan Carlos, Moyano Brandi, Nicolas, Capó, Joaquín, Noceti, Maximiliano, Ariza, Pedro Pablo, Moura Cunha, Guilherme
Format: Article
Language:English
Subjects:
Benign
Correlation coefficient
Correlation coefficients
Diagnostic systems
Gastroenterology
Hepatobiliary
Hepatology
Imaging
Lesions
Liver
Liver cancer
Magnetic resonance imaging
Medicine
Medicine & Public Health
Radiology
Shear stiffness
Statistical analysis
Tumors
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Summary:Objectives To evaluate the feasibility and diagnostic value of using a 2D spin-echo MR elastography (SE-MRE) sequence at 3.0 Tesla for solid focal liver lesions (FLL) characterization. Methods This prospective study included 55 patients with solid FLL (size > 20 mm), who underwent liver SE-MRE at 3 Tesla between 2016 and 2019. Stiffness measurements were performed by two independent readers blinded to the complete MRI exam or patient information. Histological confirmation or typical behavior on the complete MRI exam evaluated in consensus by expert abdominal radiologists was used as reference standard. FLLs were grouped and compared (malignant vs. benign) using the Mann–Whitney and Kruskal–Wallis tests. MRE diagnostic performance was assessed, and stiffness cutoffs were obtained by analysis of ROC curves from accuracy maximization. A linear regression plot was used to evaluate inter-rater agreement for FLLs stiffness measurements. p values 
ISSN:2366-004X
2366-0058
DOI:10.1007/s00261-020-02828-5