Analysis of Cytoprotective Properties of Afobazole in Streptozotocin Model of Diabetes

Previous in vitro and in vivo studies revealed the neuroprotective effect of anxiolytic Afobazole. Based on similarities in the regulation of functions of neurons and β cells, we studied the effect of Afobazole on streptozotocin (STZ) model of type 2 diabetes in Wistar rats. Immunohistochemical anal...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2020-10, Vol.169 (6), p.783-786
Main Authors: Ivanov, S. V., Ostrovskaya, R. U., Sorokina, A. V., Seredenin, S. B.
Format: Article
Language:English
Subjects:
Analysis
Animal models
Animals
Anti-Anxiety Agents - pharmacology
Benzimidazoles - pharmacology
Beta cells
Biomedical and Life Sciences
Biomedicine
Blood Glucose - metabolism
Blood sugar
Cell Biology
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Experimental - chemically induced
Diabetes Mellitus, Experimental - drug therapy
Diabetes Mellitus, Experimental - metabolism
Diabetes Mellitus, Experimental - pathology
Drug Repositioning
Gene Expression
Hypoglycemic Agents - pharmacology
Insulin-Secreting Cells - drug effects
Insulin-Secreting Cells - metabolism
Insulin-Secreting Cells - pathology
Internal Medicine
Laboratory Medicine
Male
Morpholines - pharmacology
Neuroprotection
Neuroprotective Agents - pharmacology
Pancreas
Pancreatic beta cells
Pathology
Rats
Rats, Wistar
Receptors, sigma - genetics
Receptors, sigma - metabolism
Sigma-1 Receptor
Streptozocin
Treatment Outcome
Type 2 diabetes
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Summary:Previous in vitro and in vivo studies revealed the neuroprotective effect of anxiolytic Afobazole. Based on similarities in the regulation of functions of neurons and β cells, we studied the effect of Afobazole on streptozotocin (STZ) model of type 2 diabetes in Wistar rats. Immunohistochemical analysis showed that the decrease in the number of β cells and a violation of their morphological structure caused by STZ were significantly alleviated by Afobazole administration (10 mg/kg orally for 28 days) to diabetic animals. A correlation between morphometric data and blood glucose level was revealed. A possible role of σ 1 -receptors in the cytoprotective effects of Afobazole in respect to pancreatic β cells is discussed.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-020-04978-4