Utility of Intraoperative Fluorescence Imaging in Gynecologic Surgery: Systematic Review and Consensus Statement

Background This study aimed to review the current knowledge on the utility of intraoperative fluorescence imaging in gynecologic surgery and to give evidence-based recommendations to improve the quality of care for women who undergo gynecologic surgery. Methods A computer-based systematic review of...

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Bibliographic Details
Published in:Annals of surgical oncology 2021-06, Vol.28 (6), p.3266-3278
Main Authors: Zapardiel, Ignacio, Alvarez, Julio, Barahona, Manel, Barri, Pere, Boldo, Ana, Bresco, Pera, Gasca, Isabel, Jaunarena, Ibon, Kucukmetin, Ali, Mancebo, Gloria, Otero, Borja, Roldan, Fernando, Rovira, Ramón, Suarez, Enma, Tejerizo, Alvaro, Torrent, Anna, Gorostidi, Mikel
Format: Article
Language:English
Subjects:
Cancer
Cervical cancer
Cervix
Coloring Agents
Consensus
Endometrium
Female
Fluorescence
Genital cancers
Gynecologic Oncology
Gynecologic Surgical Procedures
Gynecology
Humans
Indocyanine Green
Mapping
Medicine
Medicine & Public Health
Oncology
Optical Imaging
Ovarian cancer
Reviews
Sentinel Lymph Node
Sentinel Lymph Node Biopsy
Surgery
Surgical Oncology
Systematic review
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Summary:Background This study aimed to review the current knowledge on the utility of intraoperative fluorescence imaging in gynecologic surgery and to give evidence-based recommendations to improve the quality of care for women who undergo gynecologic surgery. Methods A computer-based systematic review of the MEDLINE, CENTRAL, Pubmed, EMBASE, and SciSearch databases as well as institutional guidelines was performed. The time limit was set at 2000–2019. For the literature search, PRISMA guidelines were followed. A modified-Delphi method was performed in three rounds by a panel of experts to reach a consensus of conclusions and recommendations. Results Indocyanine green (ICG) is used primarily in gynecology for sentinel node-mapping. In endometrial and cervical cancer, ICG is a feasible, safe, time-efficient, and reliable method for lymphatic mapping, with better bilateral detection rates. Experience in vulvar cancer is more limited, with ICG used together with Tc-99 m as a dual tracer and alone in video endoscopic inguinal lymphadenectomy. In early ovarian cancer, results are still preliminary but promising. Indocyanine green fluorescence imaging also is used for ureteral assessment, allowing intraoperative ureteral visualization, to reduce the risk of ureteral injury during gynecologic surgery. Conclusions For most gynecologic cancers, ICG fluorescence imaging is considered the tracer of choice for lymphatic mapping. The use of this new technology expands to a better ureteral assessment.
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-020-09222-x