Effect of Age and Acute Exercise on Circulating Angioregulatory Factors

The balance of angiogenic factors, including vascular endothelial growth factor (VEGF), and angiostatic factors, like thrombospondin-1 (TSP-1) and endostatin, controls striated muscle angiogenic responses to exercise training. The effect of age on circulating levels of these factors following a bout...

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Bibliographic Details
Published in:Journal of aging and physical activity 2021-06, Vol.29 (3), p.423-430
Main Authors: Luttrell, Meredith J, Mardis, Benjamin R, Bock, Joshua M, Iwamoto, Erika, Hanada, Satoshi, Ueda, Kenichi, Feider, Andrew J, Temperly, Kenzie, Casey, Darren
Format: Article
Language:English
Subjects:
Adult
Age
Age Factors
Aged
Endostatins - blood
Exercise
Female
Humans
Male
Middle Aged
Muscle, Skeletal
Older people
Serum
Thrombospondin 1 - blood
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A - blood
Young Adult
Young adults
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Summary:The balance of angiogenic factors, including vascular endothelial growth factor (VEGF), and angiostatic factors, like thrombospondin-1 (TSP-1) and endostatin, controls striated muscle angiogenic responses to exercise training. The effect of age on circulating levels of these factors following a bout of exercise is unclear. The authors hypothesized that older adults would have lower circulating VEGF but higher TSP-1 and endostatin after exercise compared with young adults. Ten young and nine older participants cycled for 45 min at 60% estimated HRmax. Serum [VEGF], [TSP-1], and [endostatin] obtained before (PREX), immediately after (POSTX0), and 3 hr after (POSTX3) exercise were analyzed. [VEGF] increased in older adults only from PREX to POSTX0 (p < .05). [TSP-1] increased in both age groups (p < .05). There was no effect of age or exercise on [endostatin]. In conclusion, immediately after exercise, both groups had a similar increase in [TSP-1], but [VEGF] increased in older adults only.
ISSN:1063-8652
1543-267X
DOI:10.1123/japa.2020-0024