A systematic review of post-translational modifications in the mitochondrial permeability transition pore complex associated with cardiac diseases

• Published in: Biochimica et biophysica acta. Molecular basis of disease 2021-01, Vol.1867 (1), p.165992-165992, Article 165992
• Main Authors: Alves-Figueiredo, H., Silva-Platas, C., Lozano, O., Vázquez-Garza, E., Guerrero-Beltrán, C.E., Zarain-Herzberg, A., García-Rivas, G.
• Format: Article
• Language: English
• Subjects: Cardiac disease; Cardiac physiology; Cardiac physiopathology; Diabetic cardiomyopathy; Heart failure; Heart Failure - metabolism; Heart Failure - pathology; Humans; Ischemia/reperfusion injury; Mitochondria, Heart - metabolism; Mitochondria, Heart - pathology; Mitochondrial permeability transition pore; Mitochondrial Permeability Transition Pore - metabolism; Myocardial Reperfusion Injury - metabolism; Myocardial Reperfusion Injury - pathology; Obesity cardiomyopathy; Post-translational modifications; Protein Processing, Post-Translational; Proteomics; Systematic review
• ISSN: 0925-4439; 1879-260X
• DOI: 10.1016/j.bbadis.2020.165992

The mitochondrial permeability transition pore (mPTP) opening is involved in the pathophysiology of multiple cardiac diseases, such as ischemia/reperfusion injury and heart failure. A growing number of evidence provided by proteomic screening techniques has demonstrated the role of post-translational modifications (PTMs) in several key components of the pore in response to changes in the extra/intracellular environment and bioenergetic demand. This could lead to a fine, complex regulatory mechanism that, under pathological conditions, can shift the state of mitochondrial functions and, thus, the cell's fate. Understanding the complex relationship between these PTMs is still under investigation and can provide new, promising therapeutic targets and treatment approaches. This review, using a systematic review of the literature, presents the current knowledge on PTMs of the mPTP and their role in health and cardiac disease. Systematic review on the PMTs of the mPTP in cardiac physiology and disease. Using cross-reference data between published articles and protein databases to achieve the most complete and up-to-date compilation of PTMs with a physiological and pathophysiological role in the function of the mPTP. [Display omitted] •The mitochondrial permeability transition pore is deeply implicated in cardiac disease.•Post-translational modifications are a proteome fine-tuning regulatory mechanisms.•Large amount of post-translational modifications data over mPTP without contextualization•Systematic revision compiles most up-to-date post-translational modifications.•Integrating post-translational modifications in mPTP with physiological role in cardiac diseases