Eucapnic voluntary hyperventilation test decreases exhaled nitric oxide level in children

Background Exhaled nitric oxide (FeNO) measurements and eucapnic voluntary hyperventilation (EVH) tests have been used as diagnostic tools for asthma. Data on the impact of hyperventilation on the level of FeNO are limited. Aim We aimed to evaluate whether EVH tests affect the level of FeNO in child...

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Bibliographic Details
Published in:Clinical physiology and functional imaging 2021-01, Vol.41 (1), p.1-3
Main Authors: Burman, Janne, Malmberg, Pekka, Elenius, Varpu, Lukkarinen, Heikki, Kuusela, Tom, Mäkelä, Mika, Remes, Sami, Jartti, Tuomas
Format: Article
Language:English
Subjects:
Allergens
Asthma
Bronchoconstriction
Children
Diagnostic software
Diagnostic systems
eucapnic voluntary hyperventilation test
exhaled nitric oxide
FeNO
Hyperventilation
indirect bronchial challenge test
Nitric oxide
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Summary:Background Exhaled nitric oxide (FeNO) measurements and eucapnic voluntary hyperventilation (EVH) tests have been used as diagnostic tools for asthma. Data on the impact of hyperventilation on the level of FeNO are limited. Aim We aimed to evaluate whether EVH tests affect the level of FeNO in children aged 10–16 years. Methods A total of 234 children aged 10–16 years had a 6‐min EVH test performed. In total, FeNO values for 153 of 234 children were measured before the test and within 15 min after the test. According to a baseline FeNO level of 20 ppb, children were divided into two groups: those with low values (FeNO 
ISSN:1475-0961
1475-097X
DOI:10.1111/cpf.12673