Less Is More: Rare Pulmonary Neuroendocrine Cells Function as Critical Sensors in Lung

Pulmonary neuroendocrine cells (PNECs) are rare airway epithelial cells that also uniquely harbor neuronal and endocrine characteristics. In vitro data indicate that these cells respond to chemical or mechanical stimuli by releasing neuropeptides and neurotransmitters, implicating them as airway sen...

Full description

Saved in:
Bibliographic Details
Published in:Developmental cell 2020-10, Vol.55 (2), p.123-132
Main Authors: Xu, Jinhao, Yu, Haoze, Sun, Xin
Format: Article
Language:English
Subjects:
Animals
Epithelial Cells - immunology
Epithelial Cells - metabolism
Epithelium - immunology
Epithelium - metabolism
Humans
Lung - immunology
Lung - metabolism
Neuroendocrine Cells - immunology
Neuroendocrine Cells - metabolism
Neuropeptides - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c353t-3f43bacc7c50d131432e61b37540734cc420fc14da721a04c073f7473df5e99f3
cites cdi_FETCH-LOGICAL-c353t-3f43bacc7c50d131432e61b37540734cc420fc14da721a04c073f7473df5e99f3
container_end_page 132
container_issue 2
container_start_page 123
container_title Developmental cell
container_volume 55
creator Xu, Jinhao
Yu, Haoze
Sun, Xin
description Pulmonary neuroendocrine cells (PNECs) are rare airway epithelial cells that also uniquely harbor neuronal and endocrine characteristics. In vitro data indicate that these cells respond to chemical or mechanical stimuli by releasing neuropeptides and neurotransmitters, implicating them as airway sensors. Emerging in vivo data corroborate this role and demonstrate that PNECs are important for lung response to signals, such as allergens. With close proximity to steady-state immune cells and innervating nerves, PNECs, as prototype tissue-resident neuroendocrine cells, are at the center of a neuro-immune module that enables the fundamental ability of an organ to sense and respond to the environment.
doi_str_mv 10.1016/j.devcel.2020.09.024
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2455171298</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2455171298</sourcerecordid><originalsourceid>FETCH-LOGICAL-c353t-3f43bacc7c50d131432e61b37540734cc420fc14da721a04c073f7473df5e99f3</originalsourceid><addsrcrecordid>eNo9kMtOwzAQRS0EoqXwBwh5ySbBju06YYciCpXCQ7y2lutMUKrELnaCxN_jqoXVjEb3zGgOQueUpJTQ-dU6reHbQJdmJCMpKVKS8QM0pbnMEyoEPYy9YDwROZETdBLCmkSM5uQYTRijJJdCTNFHBSHgZcAPzsM1ftEe8PPY9c5q_4MfYfQObO2Mby3gErou4MVozdA6i3XApW-H1ugOv4INzgfcWlyN9vMUHTW6C3C2rzP0vrh9K--T6uluWd5UiWGCDQlrOFtpY6QRpKaMcpbBnK6YFJxIxo3hGWkM5bWWGdWEmzhtJJesbgQURcNm6HK3d-Pd1whhUH0bopROW3BjUBmPJiTNijxG-S5qvAvBQ6M2vu3jl4oStTWq1mpnVG2NKlKoaDRiF_sL46qH-h_6U8h-ASurcr8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2455171298</pqid></control><display><type>article</type><title>Less Is More: Rare Pulmonary Neuroendocrine Cells Function as Critical Sensors in Lung</title><source>BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS</source><creator>Xu, Jinhao ; Yu, Haoze ; Sun, Xin</creator><creatorcontrib>Xu, Jinhao ; Yu, Haoze ; Sun, Xin</creatorcontrib><description>Pulmonary neuroendocrine cells (PNECs) are rare airway epithelial cells that also uniquely harbor neuronal and endocrine characteristics. In vitro data indicate that these cells respond to chemical or mechanical stimuli by releasing neuropeptides and neurotransmitters, implicating them as airway sensors. Emerging in vivo data corroborate this role and demonstrate that PNECs are important for lung response to signals, such as allergens. With close proximity to steady-state immune cells and innervating nerves, PNECs, as prototype tissue-resident neuroendocrine cells, are at the center of a neuro-immune module that enables the fundamental ability of an organ to sense and respond to the environment.</description><identifier>ISSN: 1534-5807</identifier><identifier>EISSN: 1878-1551</identifier><identifier>DOI: 10.1016/j.devcel.2020.09.024</identifier><identifier>PMID: 33108755</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Epithelial Cells - immunology ; Epithelial Cells - metabolism ; Epithelium - immunology ; Epithelium - metabolism ; Humans ; Lung - immunology ; Lung - metabolism ; Neuroendocrine Cells - immunology ; Neuroendocrine Cells - metabolism ; Neuropeptides - metabolism</subject><ispartof>Developmental cell, 2020-10, Vol.55 (2), p.123-132</ispartof><rights>Copyright © 2020 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-3f43bacc7c50d131432e61b37540734cc420fc14da721a04c073f7473df5e99f3</citedby><cites>FETCH-LOGICAL-c353t-3f43bacc7c50d131432e61b37540734cc420fc14da721a04c073f7473df5e99f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33108755$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Jinhao</creatorcontrib><creatorcontrib>Yu, Haoze</creatorcontrib><creatorcontrib>Sun, Xin</creatorcontrib><title>Less Is More: Rare Pulmonary Neuroendocrine Cells Function as Critical Sensors in Lung</title><title>Developmental cell</title><addtitle>Dev Cell</addtitle><description>Pulmonary neuroendocrine cells (PNECs) are rare airway epithelial cells that also uniquely harbor neuronal and endocrine characteristics. In vitro data indicate that these cells respond to chemical or mechanical stimuli by releasing neuropeptides and neurotransmitters, implicating them as airway sensors. Emerging in vivo data corroborate this role and demonstrate that PNECs are important for lung response to signals, such as allergens. With close proximity to steady-state immune cells and innervating nerves, PNECs, as prototype tissue-resident neuroendocrine cells, are at the center of a neuro-immune module that enables the fundamental ability of an organ to sense and respond to the environment.</description><subject>Animals</subject><subject>Epithelial Cells - immunology</subject><subject>Epithelial Cells - metabolism</subject><subject>Epithelium - immunology</subject><subject>Epithelium - metabolism</subject><subject>Humans</subject><subject>Lung - immunology</subject><subject>Lung - metabolism</subject><subject>Neuroendocrine Cells - immunology</subject><subject>Neuroendocrine Cells - metabolism</subject><subject>Neuropeptides - metabolism</subject><issn>1534-5807</issn><issn>1878-1551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNo9kMtOwzAQRS0EoqXwBwh5ySbBju06YYciCpXCQ7y2lutMUKrELnaCxN_jqoXVjEb3zGgOQueUpJTQ-dU6reHbQJdmJCMpKVKS8QM0pbnMEyoEPYy9YDwROZETdBLCmkSM5uQYTRijJJdCTNFHBSHgZcAPzsM1ftEe8PPY9c5q_4MfYfQObO2Mby3gErou4MVozdA6i3XApW-H1ugOv4INzgfcWlyN9vMUHTW6C3C2rzP0vrh9K--T6uluWd5UiWGCDQlrOFtpY6QRpKaMcpbBnK6YFJxIxo3hGWkM5bWWGdWEmzhtJJesbgQURcNm6HK3d-Pd1whhUH0bopROW3BjUBmPJiTNijxG-S5qvAvBQ6M2vu3jl4oStTWq1mpnVG2NKlKoaDRiF_sL46qH-h_6U8h-ASurcr8</recordid><startdate>20201026</startdate><enddate>20201026</enddate><creator>Xu, Jinhao</creator><creator>Yu, Haoze</creator><creator>Sun, Xin</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20201026</creationdate><title>Less Is More: Rare Pulmonary Neuroendocrine Cells Function as Critical Sensors in Lung</title><author>Xu, Jinhao ; Yu, Haoze ; Sun, Xin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-3f43bacc7c50d131432e61b37540734cc420fc14da721a04c073f7473df5e99f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Epithelial Cells - immunology</topic><topic>Epithelial Cells - metabolism</topic><topic>Epithelium - immunology</topic><topic>Epithelium - metabolism</topic><topic>Humans</topic><topic>Lung - immunology</topic><topic>Lung - metabolism</topic><topic>Neuroendocrine Cells - immunology</topic><topic>Neuroendocrine Cells - metabolism</topic><topic>Neuropeptides - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Jinhao</creatorcontrib><creatorcontrib>Yu, Haoze</creatorcontrib><creatorcontrib>Sun, Xin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Jinhao</au><au>Yu, Haoze</au><au>Sun, Xin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Less Is More: Rare Pulmonary Neuroendocrine Cells Function as Critical Sensors in Lung</atitle><jtitle>Developmental cell</jtitle><addtitle>Dev Cell</addtitle><date>2020-10-26</date><risdate>2020</risdate><volume>55</volume><issue>2</issue><spage>123</spage><epage>132</epage><pages>123-132</pages><issn>1534-5807</issn><eissn>1878-1551</eissn><abstract>Pulmonary neuroendocrine cells (PNECs) are rare airway epithelial cells that also uniquely harbor neuronal and endocrine characteristics. In vitro data indicate that these cells respond to chemical or mechanical stimuli by releasing neuropeptides and neurotransmitters, implicating them as airway sensors. Emerging in vivo data corroborate this role and demonstrate that PNECs are important for lung response to signals, such as allergens. With close proximity to steady-state immune cells and innervating nerves, PNECs, as prototype tissue-resident neuroendocrine cells, are at the center of a neuro-immune module that enables the fundamental ability of an organ to sense and respond to the environment.</abstract><cop>United States</cop><pmid>33108755</pmid><doi>10.1016/j.devcel.2020.09.024</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1534-5807
ispartof Developmental cell, 2020-10, Vol.55 (2), p.123-132
issn 1534-5807
1878-1551
language eng
recordid cdi_proquest_miscellaneous_2455171298
source BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS
subjects Animals
Epithelial Cells - immunology
Epithelial Cells - metabolism
Epithelium - immunology
Epithelium - metabolism
Humans
Lung - immunology
Lung - metabolism
Neuroendocrine Cells - immunology
Neuroendocrine Cells - metabolism
Neuropeptides - metabolism
title Less Is More: Rare Pulmonary Neuroendocrine Cells Function as Critical Sensors in Lung
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T00%3A08%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Less%20Is%20More:%20Rare%20Pulmonary%20Neuroendocrine%20Cells%20Function%20as%20Critical%20Sensors%20in%20Lung&rft.jtitle=Developmental%20cell&rft.au=Xu,%20Jinhao&rft.date=2020-10-26&rft.volume=55&rft.issue=2&rft.spage=123&rft.epage=132&rft.pages=123-132&rft.issn=1534-5807&rft.eissn=1878-1551&rft_id=info:doi/10.1016/j.devcel.2020.09.024&rft_dat=%3Cproquest_cross%3E2455171298%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c353t-3f43bacc7c50d131432e61b37540734cc420fc14da721a04c073f7473df5e99f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2455171298&rft_id=info:pmid/33108755&rfr_iscdi=true