Impact of Palifermin on Transplant Outcomes in Children and Adolescents Undergoing Allogeneic Hematopoietic Cell Transplantation

Background: Oral mucositis (OM) is considered to be one of the worst and most debilitating complications of conditioning for hematopoietic cell transplantation (HCT). Prevention and treatment of this complication is one of the utmost priorities of supportive therapy during transplant procedure. The...

Full description

Saved in:
Bibliographic Details
Published in:Anticancer research 2020-11, Vol.40 (11), p.6531-6537
Main Authors: CZYŻEWSKI, KRZYSZTOF, DĘBSKI, ROBERT, BARTOSZEWICZ, NATALIA, DEMIDOWICZ, EWA, RICHERT-PRZYGOŃSKA, MONIKA, ŁĘCKA, MONIKA, TARASENKO, SONIA, STYCZYŃSKI, JAN
Format: Article
Language:English
Subjects:
Adolescents
Children
Complications
Graft-versus-host reaction
Growth factors
Keratinocyte growth factor
Mucositis
Risk analysis
Risk factors
Stem cell transplantation
Survival
Transplantation
Transplants & implants
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 6537
container_issue 11
container_start_page 6531
container_title Anticancer research
container_volume 40
creator CZYŻEWSKI, KRZYSZTOF
DĘBSKI, ROBERT
BARTOSZEWICZ, NATALIA
DEMIDOWICZ, EWA
RICHERT-PRZYGOŃSKA, MONIKA
ŁĘCKA, MONIKA
TARASENKO, SONIA
STYCZYŃSKI, JAN
description Background: Oral mucositis (OM) is considered to be one of the worst and most debilitating complications of conditioning for hematopoietic cell transplantation (HCT). Prevention and treatment of this complication is one of the utmost priorities of supportive therapy during transplant procedure. The objective of this study was the analysis of the influence of palifermin, keratinocyte growth factor (KGF), on transplant outcomes in patients undergoing allo-HCT. Patients and Methods: A total of 253 allo-HCTs performed between 2003-2018 in patients aged 0-19 years at a single center were analyzed. KGF was administered in 161 HCTs. Uni- and multivariate risk factor analyses were performed. Results: In spite of reducing the duration and grade of mucositis, no prognostic impact of KGF was shown for overall survival, event-free survival, relapse incidence, acute and chronic graft-versus-host disease (GVHD), nor GVHD-free relapse-free survival. Conclusion: Palifermin had no impact on transplant outcomes in children and adolescents undergoing allo-HCT.
doi_str_mv 10.21873/anticanres.14677
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2455171498</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2455171498</sourcerecordid><originalsourceid>FETCH-LOGICAL-c301t-8d0d52f0c71833247bb1a9b56624e447407ecba69ed9649dc05407be81cbe45e3</originalsourceid><addsrcrecordid>eNpdkUFLwzAUx4MoOKcfwFvAi5fOpEma9jiGusFgHrZzSdPXmZEmNekO3vzoRiconh689-PPj_dH6JaSWU5LyR6UG41WLkCcUV5IeYYmVFY0k4KRczQhuSCZJERcoqsYD4QURVWyCfpY9YPSI_YdflHWdBB647B3eBuUi4NNsXhzHLXvIeJ0Wbwa2wZwWLkWz1tvIWpwY8Q710LYe-P2eG6t34MDo_ESejX6wRtIdngB1v4JVqPx7hpddMpGuPmZU7R7etwultl687xazNeZZoSOWdmSVuQd0ZKWjOVcNg1VVSOKIufAueREgm5UUUFbFbxqNRFp1UBJdQNcAJui-1PuEPzbEeJY9yap2yQC_hjrnAtBJeXpK1N09w89-GNwye6LKqUUJaOJoidKBx9jgK4egulVeK8pqb87qX87qb87YZ-B1oQb</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2458775831</pqid></control><display><type>article</type><title>Impact of Palifermin on Transplant Outcomes in Children and Adolescents Undergoing Allogeneic Hematopoietic Cell Transplantation</title><source>EZB Free E-Journals</source><creator>CZYŻEWSKI, KRZYSZTOF ; DĘBSKI, ROBERT ; BARTOSZEWICZ, NATALIA ; DEMIDOWICZ, EWA ; RICHERT-PRZYGOŃSKA, MONIKA ; ŁĘCKA, MONIKA ; TARASENKO, SONIA ; STYCZYŃSKI, JAN</creator><creatorcontrib>CZYŻEWSKI, KRZYSZTOF ; DĘBSKI, ROBERT ; BARTOSZEWICZ, NATALIA ; DEMIDOWICZ, EWA ; RICHERT-PRZYGOŃSKA, MONIKA ; ŁĘCKA, MONIKA ; TARASENKO, SONIA ; STYCZYŃSKI, JAN</creatorcontrib><description>Background: Oral mucositis (OM) is considered to be one of the worst and most debilitating complications of conditioning for hematopoietic cell transplantation (HCT). Prevention and treatment of this complication is one of the utmost priorities of supportive therapy during transplant procedure. The objective of this study was the analysis of the influence of palifermin, keratinocyte growth factor (KGF), on transplant outcomes in patients undergoing allo-HCT. Patients and Methods: A total of 253 allo-HCTs performed between 2003-2018 in patients aged 0-19 years at a single center were analyzed. KGF was administered in 161 HCTs. Uni- and multivariate risk factor analyses were performed. Results: In spite of reducing the duration and grade of mucositis, no prognostic impact of KGF was shown for overall survival, event-free survival, relapse incidence, acute and chronic graft-versus-host disease (GVHD), nor GVHD-free relapse-free survival. Conclusion: Palifermin had no impact on transplant outcomes in children and adolescents undergoing allo-HCT.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>DOI: 10.21873/anticanres.14677</identifier><language>eng</language><publisher>Athens: International Institute of Anticancer Research</publisher><subject>Adolescents ; Children ; Complications ; Graft-versus-host reaction ; Growth factors ; Keratinocyte growth factor ; Mucositis ; Risk analysis ; Risk factors ; Stem cell transplantation ; Survival ; Transplantation ; Transplants &amp; implants</subject><ispartof>Anticancer research, 2020-11, Vol.40 (11), p.6531-6537</ispartof><rights>Copyright International Institute of Anticancer Research Nov 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-7704-7518</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>CZYŻEWSKI, KRZYSZTOF</creatorcontrib><creatorcontrib>DĘBSKI, ROBERT</creatorcontrib><creatorcontrib>BARTOSZEWICZ, NATALIA</creatorcontrib><creatorcontrib>DEMIDOWICZ, EWA</creatorcontrib><creatorcontrib>RICHERT-PRZYGOŃSKA, MONIKA</creatorcontrib><creatorcontrib>ŁĘCKA, MONIKA</creatorcontrib><creatorcontrib>TARASENKO, SONIA</creatorcontrib><creatorcontrib>STYCZYŃSKI, JAN</creatorcontrib><title>Impact of Palifermin on Transplant Outcomes in Children and Adolescents Undergoing Allogeneic Hematopoietic Cell Transplantation</title><title>Anticancer research</title><description>Background: Oral mucositis (OM) is considered to be one of the worst and most debilitating complications of conditioning for hematopoietic cell transplantation (HCT). Prevention and treatment of this complication is one of the utmost priorities of supportive therapy during transplant procedure. The objective of this study was the analysis of the influence of palifermin, keratinocyte growth factor (KGF), on transplant outcomes in patients undergoing allo-HCT. Patients and Methods: A total of 253 allo-HCTs performed between 2003-2018 in patients aged 0-19 years at a single center were analyzed. KGF was administered in 161 HCTs. Uni- and multivariate risk factor analyses were performed. Results: In spite of reducing the duration and grade of mucositis, no prognostic impact of KGF was shown for overall survival, event-free survival, relapse incidence, acute and chronic graft-versus-host disease (GVHD), nor GVHD-free relapse-free survival. Conclusion: Palifermin had no impact on transplant outcomes in children and adolescents undergoing allo-HCT.</description><subject>Adolescents</subject><subject>Children</subject><subject>Complications</subject><subject>Graft-versus-host reaction</subject><subject>Growth factors</subject><subject>Keratinocyte growth factor</subject><subject>Mucositis</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Stem cell transplantation</subject><subject>Survival</subject><subject>Transplantation</subject><subject>Transplants &amp; implants</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpdkUFLwzAUx4MoOKcfwFvAi5fOpEma9jiGusFgHrZzSdPXmZEmNekO3vzoRiconh689-PPj_dH6JaSWU5LyR6UG41WLkCcUV5IeYYmVFY0k4KRczQhuSCZJERcoqsYD4QURVWyCfpY9YPSI_YdflHWdBB647B3eBuUi4NNsXhzHLXvIeJ0Wbwa2wZwWLkWz1tvIWpwY8Q710LYe-P2eG6t34MDo_ESejX6wRtIdngB1v4JVqPx7hpddMpGuPmZU7R7etwultl687xazNeZZoSOWdmSVuQd0ZKWjOVcNg1VVSOKIufAueREgm5UUUFbFbxqNRFp1UBJdQNcAJui-1PuEPzbEeJY9yap2yQC_hjrnAtBJeXpK1N09w89-GNwye6LKqUUJaOJoidKBx9jgK4egulVeK8pqb87qX87qb87YZ-B1oQb</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>CZYŻEWSKI, KRZYSZTOF</creator><creator>DĘBSKI, ROBERT</creator><creator>BARTOSZEWICZ, NATALIA</creator><creator>DEMIDOWICZ, EWA</creator><creator>RICHERT-PRZYGOŃSKA, MONIKA</creator><creator>ŁĘCKA, MONIKA</creator><creator>TARASENKO, SONIA</creator><creator>STYCZYŃSKI, JAN</creator><general>International Institute of Anticancer Research</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7704-7518</orcidid></search><sort><creationdate>20201101</creationdate><title>Impact of Palifermin on Transplant Outcomes in Children and Adolescents Undergoing Allogeneic Hematopoietic Cell Transplantation</title><author>CZYŻEWSKI, KRZYSZTOF ; DĘBSKI, ROBERT ; BARTOSZEWICZ, NATALIA ; DEMIDOWICZ, EWA ; RICHERT-PRZYGOŃSKA, MONIKA ; ŁĘCKA, MONIKA ; TARASENKO, SONIA ; STYCZYŃSKI, JAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-8d0d52f0c71833247bb1a9b56624e447407ecba69ed9649dc05407be81cbe45e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescents</topic><topic>Children</topic><topic>Complications</topic><topic>Graft-versus-host reaction</topic><topic>Growth factors</topic><topic>Keratinocyte growth factor</topic><topic>Mucositis</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Stem cell transplantation</topic><topic>Survival</topic><topic>Transplantation</topic><topic>Transplants &amp; implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CZYŻEWSKI, KRZYSZTOF</creatorcontrib><creatorcontrib>DĘBSKI, ROBERT</creatorcontrib><creatorcontrib>BARTOSZEWICZ, NATALIA</creatorcontrib><creatorcontrib>DEMIDOWICZ, EWA</creatorcontrib><creatorcontrib>RICHERT-PRZYGOŃSKA, MONIKA</creatorcontrib><creatorcontrib>ŁĘCKA, MONIKA</creatorcontrib><creatorcontrib>TARASENKO, SONIA</creatorcontrib><creatorcontrib>STYCZYŃSKI, JAN</creatorcontrib><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CZYŻEWSKI, KRZYSZTOF</au><au>DĘBSKI, ROBERT</au><au>BARTOSZEWICZ, NATALIA</au><au>DEMIDOWICZ, EWA</au><au>RICHERT-PRZYGOŃSKA, MONIKA</au><au>ŁĘCKA, MONIKA</au><au>TARASENKO, SONIA</au><au>STYCZYŃSKI, JAN</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Palifermin on Transplant Outcomes in Children and Adolescents Undergoing Allogeneic Hematopoietic Cell Transplantation</atitle><jtitle>Anticancer research</jtitle><date>2020-11-01</date><risdate>2020</risdate><volume>40</volume><issue>11</issue><spage>6531</spage><epage>6537</epage><pages>6531-6537</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Background: Oral mucositis (OM) is considered to be one of the worst and most debilitating complications of conditioning for hematopoietic cell transplantation (HCT). Prevention and treatment of this complication is one of the utmost priorities of supportive therapy during transplant procedure. The objective of this study was the analysis of the influence of palifermin, keratinocyte growth factor (KGF), on transplant outcomes in patients undergoing allo-HCT. Patients and Methods: A total of 253 allo-HCTs performed between 2003-2018 in patients aged 0-19 years at a single center were analyzed. KGF was administered in 161 HCTs. Uni- and multivariate risk factor analyses were performed. Results: In spite of reducing the duration and grade of mucositis, no prognostic impact of KGF was shown for overall survival, event-free survival, relapse incidence, acute and chronic graft-versus-host disease (GVHD), nor GVHD-free relapse-free survival. Conclusion: Palifermin had no impact on transplant outcomes in children and adolescents undergoing allo-HCT.</abstract><cop>Athens</cop><pub>International Institute of Anticancer Research</pub><doi>10.21873/anticanres.14677</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-7704-7518</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0250-7005
ispartof Anticancer research, 2020-11, Vol.40 (11), p.6531-6537
issn 0250-7005
1791-7530
language eng
recordid cdi_proquest_miscellaneous_2455171498
source EZB Free E-Journals
subjects Adolescents
Children
Complications
Graft-versus-host reaction
Growth factors
Keratinocyte growth factor
Mucositis
Risk analysis
Risk factors
Stem cell transplantation
Survival
Transplantation
Transplants & implants
title Impact of Palifermin on Transplant Outcomes in Children and Adolescents Undergoing Allogeneic Hematopoietic Cell Transplantation
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T07%3A05%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20Palifermin%20on%20Transplant%20Outcomes%20in%20Children%20and%20Adolescents%20Undergoing%20Allogeneic%20Hematopoietic%20Cell%20Transplantation&rft.jtitle=Anticancer%20research&rft.au=CZY%C5%BBEWSKI,%20KRZYSZTOF&rft.date=2020-11-01&rft.volume=40&rft.issue=11&rft.spage=6531&rft.epage=6537&rft.pages=6531-6537&rft.issn=0250-7005&rft.eissn=1791-7530&rft_id=info:doi/10.21873/anticanres.14677&rft_dat=%3Cproquest_cross%3E2455171498%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c301t-8d0d52f0c71833247bb1a9b56624e447407ecba69ed9649dc05407be81cbe45e3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2458775831&rft_id=info:pmid/&rfr_iscdi=true