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Efficacy of Electrochemotherapy in the Treatment of Cutaneous Melanoma Metastases and Rare Non-melanoma Skin Cancer
We aimed to verify the clinical efficacy and safety of the electrochemotherapy in melanoma metastases and in cases of rare non-melanoma tumors that were difficult to treat for the specific anatomical site or for patient comorbidities. We treated 68 patients (699 cutaneous nodules), 44 patients with...
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| Published in: | Anticancer research 2020-11, Vol.40 (11), p.6485-6492 |
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| Main Authors: | , , , , , , , |
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| container_end_page | 6492 |
| container_issue | 11 |
| container_start_page | 6485 |
| container_title | Anticancer research |
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| creator | Borgognoni, Lorenzo Pescitelli, Leonardo Gerlini, Gianni Brandani, Paola Gelli, Riccardo Giannotti, Vanni Bellucci, Francesco Sestini, Serena |
| description | We aimed to verify the clinical efficacy and safety of the electrochemotherapy in melanoma metastases and in cases of rare non-melanoma tumors that were difficult to treat for the specific anatomical site or for patient comorbidities.
We treated 68 patients (699 cutaneous nodules), 44 patients with metastatic melanomas and 24 patients with non-melanoma tumors, at the Melanoma & Skin Cancer Unit, Florence, Italy.
We obtained an objective response of 89.7% (88.6% in melanomas and 91.7% in non-melanoma tumors), complete response 54.4% and partial response 35.3%.
This study showed that electrochemotherapy is effective in the treatment of melanoma metastases and in rare types of non-melanoma tumors. In particular, we successfully treated rare tumors as angiosarcoma, pleomorphic sarcoma, myxofibrosarcoma, sarcoma di Kaposi, porocarcinoma, sebaceous carcinoma, Merkel cell carcinoma, malignant blue nevus, undifferentiated epitheliomorphic cell neoplasia and metastases from thyroid carcinoma. No serious adverse events were observed. |
| doi_str_mv | 10.21873/anticanres.14670 |
| format | article |
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We treated 68 patients (699 cutaneous nodules), 44 patients with metastatic melanomas and 24 patients with non-melanoma tumors, at the Melanoma & Skin Cancer Unit, Florence, Italy.
We obtained an objective response of 89.7% (88.6% in melanomas and 91.7% in non-melanoma tumors), complete response 54.4% and partial response 35.3%.
This study showed that electrochemotherapy is effective in the treatment of melanoma metastases and in rare types of non-melanoma tumors. In particular, we successfully treated rare tumors as angiosarcoma, pleomorphic sarcoma, myxofibrosarcoma, sarcoma di Kaposi, porocarcinoma, sebaceous carcinoma, Merkel cell carcinoma, malignant blue nevus, undifferentiated epitheliomorphic cell neoplasia and metastases from thyroid carcinoma. No serious adverse events were observed.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>DOI: 10.21873/anticanres.14670</identifier><identifier>PMID: 33109587</identifier><language>eng</language><publisher>Greece: International Institute of Anticancer Research</publisher><subject>Adult ; Bleomycin - administration & dosage ; Cancer ; Carcinoma, Merkel Cell ; Chemotherapy ; Electrochemotherapy ; Female ; Humans ; Italy - epidemiology ; Male ; Melanoma ; Melanoma - pathology ; Melanoma - therapy ; Melanoma, Cutaneous Malignant ; Metastases ; Metastasis ; Middle Aged ; Neoplasms, Second Primary - pathology ; Neoplasms, Second Primary - therapy ; Nevus ; Nodules ; Patients ; Remission Induction ; Sarcoma ; Skin cancer ; Skin Neoplasms - pathology ; Skin Neoplasms - therapy ; Thyroid ; Thyroid carcinoma ; Treatment Outcome ; Tumors</subject><ispartof>Anticancer research, 2020-11, Vol.40 (11), p.6485-6492</ispartof><rights>Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.</rights><rights>Copyright International Institute of Anticancer Research Nov 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-f80924fe06b330da035090793e8bdc7ffcecae636b93fcfaa76131c5fbc4720e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33109587$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Borgognoni, Lorenzo</creatorcontrib><creatorcontrib>Pescitelli, Leonardo</creatorcontrib><creatorcontrib>Gerlini, Gianni</creatorcontrib><creatorcontrib>Brandani, Paola</creatorcontrib><creatorcontrib>Gelli, Riccardo</creatorcontrib><creatorcontrib>Giannotti, Vanni</creatorcontrib><creatorcontrib>Bellucci, Francesco</creatorcontrib><creatorcontrib>Sestini, Serena</creatorcontrib><title>Efficacy of Electrochemotherapy in the Treatment of Cutaneous Melanoma Metastases and Rare Non-melanoma Skin Cancer</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>We aimed to verify the clinical efficacy and safety of the electrochemotherapy in melanoma metastases and in cases of rare non-melanoma tumors that were difficult to treat for the specific anatomical site or for patient comorbidities.
We treated 68 patients (699 cutaneous nodules), 44 patients with metastatic melanomas and 24 patients with non-melanoma tumors, at the Melanoma & Skin Cancer Unit, Florence, Italy.
We obtained an objective response of 89.7% (88.6% in melanomas and 91.7% in non-melanoma tumors), complete response 54.4% and partial response 35.3%.
This study showed that electrochemotherapy is effective in the treatment of melanoma metastases and in rare types of non-melanoma tumors. In particular, we successfully treated rare tumors as angiosarcoma, pleomorphic sarcoma, myxofibrosarcoma, sarcoma di Kaposi, porocarcinoma, sebaceous carcinoma, Merkel cell carcinoma, malignant blue nevus, undifferentiated epitheliomorphic cell neoplasia and metastases from thyroid carcinoma. No serious adverse events were observed.</description><subject>Adult</subject><subject>Bleomycin - administration & dosage</subject><subject>Cancer</subject><subject>Carcinoma, Merkel Cell</subject><subject>Chemotherapy</subject><subject>Electrochemotherapy</subject><subject>Female</subject><subject>Humans</subject><subject>Italy - epidemiology</subject><subject>Male</subject><subject>Melanoma</subject><subject>Melanoma - pathology</subject><subject>Melanoma - therapy</subject><subject>Melanoma, Cutaneous Malignant</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neoplasms, Second Primary - pathology</subject><subject>Neoplasms, Second Primary - therapy</subject><subject>Nevus</subject><subject>Nodules</subject><subject>Patients</subject><subject>Remission Induction</subject><subject>Sarcoma</subject><subject>Skin cancer</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin Neoplasms - therapy</subject><subject>Thyroid</subject><subject>Thyroid carcinoma</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpdkU9rGzEQxUVJaBynH6CXIMill3VGK2u1ewzGaQppC417XmblEXG6KzmS9uBvX_lPWggMzDv83uPBY-yzgFkpai1v0aWNQRcozsS80vCBTYRuRKGVhDM2gVJBoQHUBbuM8QWgqppafmQXUgpoVK0nLC6tzRFmx73ly55MCt480-DTMwXc7vjG8Sz5KhCmgVzac4sxoSM_Rv6denR-wCwSxnwUObo1_4WB-A_viuENePqTkxboDIUrdm6xj_Tp9Kfs9_1ytXgoHn9-_ba4eyyM1GUqbA1NObcEVSclrBGkggZ0I6nu1kZba8ggVbLqGmmNRdSVkMIo25m5LoHklH055m6Dfx0ppnbYREN9fyzflnOlhC6FUBm9eYe--DG43G5P1VrXTaUzJY6UCT7GQLbdhs2AYdcKaA-LtP8XaQ-LZM_1KXnsBlr_c7xNIP8CDHWK0g</recordid><startdate>202011</startdate><enddate>202011</enddate><creator>Borgognoni, Lorenzo</creator><creator>Pescitelli, Leonardo</creator><creator>Gerlini, Gianni</creator><creator>Brandani, Paola</creator><creator>Gelli, Riccardo</creator><creator>Giannotti, Vanni</creator><creator>Bellucci, Francesco</creator><creator>Sestini, Serena</creator><general>International Institute of Anticancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>202011</creationdate><title>Efficacy of Electrochemotherapy in the Treatment of Cutaneous Melanoma Metastases and Rare Non-melanoma Skin Cancer</title><author>Borgognoni, Lorenzo ; 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We treated 68 patients (699 cutaneous nodules), 44 patients with metastatic melanomas and 24 patients with non-melanoma tumors, at the Melanoma & Skin Cancer Unit, Florence, Italy.
We obtained an objective response of 89.7% (88.6% in melanomas and 91.7% in non-melanoma tumors), complete response 54.4% and partial response 35.3%.
This study showed that electrochemotherapy is effective in the treatment of melanoma metastases and in rare types of non-melanoma tumors. In particular, we successfully treated rare tumors as angiosarcoma, pleomorphic sarcoma, myxofibrosarcoma, sarcoma di Kaposi, porocarcinoma, sebaceous carcinoma, Merkel cell carcinoma, malignant blue nevus, undifferentiated epitheliomorphic cell neoplasia and metastases from thyroid carcinoma. No serious adverse events were observed.</abstract><cop>Greece</cop><pub>International Institute of Anticancer Research</pub><pmid>33109587</pmid><doi>10.21873/anticanres.14670</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Bleomycin - administration & dosage Cancer Carcinoma, Merkel Cell Chemotherapy Electrochemotherapy Female Humans Italy - epidemiology Male Melanoma Melanoma - pathology Melanoma - therapy Melanoma, Cutaneous Malignant Metastases Metastasis Middle Aged Neoplasms, Second Primary - pathology Neoplasms, Second Primary - therapy Nevus Nodules Patients Remission Induction Sarcoma Skin cancer Skin Neoplasms - pathology Skin Neoplasms - therapy Thyroid Thyroid carcinoma Treatment Outcome Tumors |
| title | Efficacy of Electrochemotherapy in the Treatment of Cutaneous Melanoma Metastases and Rare Non-melanoma Skin Cancer |
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