Effects of genetics and altitude on lung function

Objectives The aim of this work is to present a review on the impact of genetics and altitude on lung function from classic and recent studies. Data source A systematic search has been carried out in different databases of scientific studies, using keywords related to lung volumes, spirometry, altit...

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Published in:The clinical respiratory journal 2021-03, Vol.15 (3), p.247-256
Main Authors: Talaminos‐Barroso, Alejandro, Roa‐Romero, Laura M., Ortega‐Ruiz, Francisco, Cejudo‐Ramos, Pilar, Márquez‐Martín, Eduardo, Reina‐Tosina, Javier
Format: Article
Language:English
Subjects:
Altitude
Genetics
lung function
Lungs
Respiratory system
review
scientific publications
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cited_by cdi_FETCH-LOGICAL-c3880-c3d7446683f303ee4c8220eadf1ff330145712d4ca8818fc4b676146b53242b43
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container_end_page 256
container_issue 3
container_start_page 247
container_title The clinical respiratory journal
container_volume 15
creator Talaminos‐Barroso, Alejandro
Roa‐Romero, Laura M.
Ortega‐Ruiz, Francisco
Cejudo‐Ramos, Pilar
Márquez‐Martín, Eduardo
Reina‐Tosina, Javier
description Objectives The aim of this work is to present a review on the impact of genetics and altitude on lung function from classic and recent studies. Data source A systematic search has been carried out in different databases of scientific studies, using keywords related to lung volumes, spirometry, altitude and genetics. Results The results of this work have been structured into three parts. First, the relationship between genes and lung function. Next, a review of the genetic predispositions related to respiratory adaptation of people who inhabit high‐altitude regions for millennia. Finally, temporary effects and long‐term acclimatisation on respiratory physiology at high altitude are presented. Conclusions The works focused on the influence of genetics and altitude on lung function are currently of interest in terms of studying the interactions between genetic, epigenetic and environmental factors in the configuration of the pathophysiological adaptation patterns.
doi_str_mv 10.1111/crj.13300
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subjects Altitude
Genetics
lung function
Lungs
Respiratory system
review
scientific publications
title Effects of genetics and altitude on lung function
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