Prognostic Value of Troponin-T and B-Type Natriuretic Peptide in Patients Hospitalized for COVID-19

COVID-19 causes severe pulmonary involvement, but the cardiovascular system can also be affected by myocarditis, heart failure and shock. The increase in cardiac biomarkers has been associated with a worse prognosis. To evaluate the prognostic value of Troponin-T (TNT) and natriuretic peptide (BNP)...

Full description

Saved in:
Bibliographic Details
Published in:Arquivos brasileiros de cardiologia 2020-10, Vol.115 (4), p.660-666
Main Authors: Almeida Junior, Gustavo Luiz Gouvêa de, Braga, Fabricio, Jorge, José Kezen, Nobre, Gustavo Freitas, Kalichsztein, Marcelo, Faria, Paula de Medeiros Pache de, Bussade, Bruno, Penna, Guilherme Loures, Alves, Vitor Oliveira, Pereira, Marcella Alecrim, Gorgulho, Paula de Castro, Faria, Milena Rego Dos Santos Espelta de, Drumond, Luis Eduardo, Carpinete, Fabrini Batista Soares, Neno, Ana Carolina Lessa Brandão, Neno, Augusto César de Araújo
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Betacoronavirus
Biomarkers - blood
Cardiovascular System - physiopathology
Cardiovascular System - virology
Coronavirus Infections - diagnosis
Coronavirus Infections - mortality
COVID-19
Female
Humans
Male
Middle Aged
Natriuretic Peptide, Brain - blood
Pandemics
Pneumonia, Viral - diagnosis
Pneumonia, Viral - mortality
Prognosis
SARS-CoV-2
Troponin T - blood
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:COVID-19 causes severe pulmonary involvement, but the cardiovascular system can also be affected by myocarditis, heart failure and shock. The increase in cardiac biomarkers has been associated with a worse prognosis. To evaluate the prognostic value of Troponin-T (TNT) and natriuretic peptide (BNP) in patients hospitalized for Covid-19. This was a convenience sample of patients hospitalized for COVID-19. Data were collected from medical records to assess the association of TnT and BNP measured in the first 24 hours of hospital admission with the combined outcome (CO) of death or need for mechanical ventilation. Univariate analysis was used to compare the groups with and without the CO. Cox's multivariate model was used to determine independent predictors of the CO. We evaluated 183 patients (age = 66.8±17 years, 65.6% of which were males). The time of follow-up was 7 days (range 1 to 39 days). The CO occurred in 24% of the patients. The median troponin-T and BNP levels were 0.011 and 0.041ng/dL (p
ISSN:1678-4170
DOI:10.36660/abc.20200385