Nulliparity and postmenopausal status are independent factors of malignancy potential of endometrial intraepithelial neoplasia in polyps

• Published in: International journal of gynecology and obstetrics 2021-03, Vol.152 (3), p.433-438
• Main Authors: Karakas, Latife Atasoy, Atilgan, Alev Ok, Akilli, Huseyin, Kuscu, Ulku Esra, Haberal, Ali, Ayhan, Ali
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Endometrial carcinoma; Endometrial Hyperplasia - epidemiology; Endometrial Hyperplasia - pathology; Endometrial intraepithelial neoplasia; Endometrial Neoplasms - epidemiology; Endometrial Neoplasms - pathology; Endometrial polyps; Female; Humans; Hysteroscopy; Malignancy; Menopause; Middle Aged; Parity; Polyps - epidemiology; Polyps - pathology; Pregnancy; Retrospective Studies; Risk Factors; Turkey - epidemiology
• ISSN: 0020-7292; 1879-3479
• DOI: 10.1002/ijgo.13448

Objective To estimate the risk of concurrent endometrial cancer in endometrium when endometrial intraepithelial neoplasia (EIN) is found within an endometrial polyp and to identify the possible predictive factors for concurrent endometrial cancer. Methods Histopathologic data of women who underwent hysteroscopy for resection of endometrial polyps at Ankara Baskent University Hospital, between 2011 and 2019 were screened. Patients whose polypectomy report was EIN in a polyp, and who had a final report of the hysterectomy specimen were included. Patients were divided into two groups according to the presence of concurrent cancer in the hysterectomy material: group 1, concurrent cancer present and group 2, concurrent cancer absent. Statistical analyses were performed using SPSS. Results A total of 4125 women underwent hysteroscopy for the resection of endometrial polyps. Of those women, 161 (3.9%) were diagnosed as having EIN and 115 met the criteria. The rate of concurrent endometrial cancer was 28.6% (33/115). According to multivariate analysis, nulliparity (odds ratio [OR] 0.38; 95% confidence interval [CI] 1.04–3.67; p = 0.036) and postmenopausal status (OR 0.64; 95% CI 0.42–0.98; p = 0.042) were found to be independent factors significantly associated with concurrent endometrial cancer. Conclusion The incidence of concurrent cancer is higher in postmenopausal or nulliparous women when EIN is detected in a polyp. Synopsis The incidence of concurrent cancer is higher in postmenopausal or nulliparous women when endometrial intraepithelial neoplasia is detected in a polyp.