Ruthenium-Catalyzed Meta-Selective C‑H Difluoromethylation of Phenol Derivatives

With pyrimidine as the directing group, we achieved the meta-selective difluoromethylation of phenol derivatives using ruthenium as a catalyst. This synthetic scheme provided an efficient method for the syntheses of fluorine-containing phenol derivatives. A wide variety of phenol derivatives were we...

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Bibliographic Details
Published in:Journal of organic chemistry 2020-11, Vol.85 (21), p.13868-13876
Main Authors: Xu, Xu, Tao, Na, Fan, Wei-Tai, Tu, Guangliang, Geng, Jingyao, Zhang, Jingyu, Zhao, Yingsheng
Format: Article
Language:English
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Summary:With pyrimidine as the directing group, we achieved the meta-selective difluoromethylation of phenol derivatives using ruthenium as a catalyst. This synthetic scheme provided an efficient method for the syntheses of fluorine-containing phenol derivatives. A wide variety of phenol derivatives were well-suited, affording the corresponding products in moderate-to-good yields.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.0c01909