Ruthenium-Catalyzed Meta-Selective C‑H Difluoromethylation of Phenol Derivatives

With pyrimidine as the directing group, we achieved the meta-selective difluoromethylation of phenol derivatives using ruthenium as a catalyst. This synthetic scheme provided an efficient method for the syntheses of fluorine-containing phenol derivatives. A wide variety of phenol derivatives were we...

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Published in:Journal of organic chemistry 2020-11, Vol.85 (21), p.13868-13876
Main Authors: Xu, Xu, Tao, Na, Fan, Wei-Tai, Tu, Guangliang, Geng, Jingyao, Zhang, Jingyu, Zhao, Yingsheng
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Language:English
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cited_by cdi_FETCH-LOGICAL-a310t-44d59146f5282705b199c96e9115cd5d29f9ea5121505c135d4efc701eca8d63
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container_end_page 13876
container_issue 21
container_start_page 13868
container_title Journal of organic chemistry
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creator Xu, Xu
Tao, Na
Fan, Wei-Tai
Tu, Guangliang
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description With pyrimidine as the directing group, we achieved the meta-selective difluoromethylation of phenol derivatives using ruthenium as a catalyst. This synthetic scheme provided an efficient method for the syntheses of fluorine-containing phenol derivatives. A wide variety of phenol derivatives were well-suited, affording the corresponding products in moderate-to-good yields.
doi_str_mv 10.1021/acs.joc.0c01909
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title Ruthenium-Catalyzed Meta-Selective C‑H Difluoromethylation of Phenol Derivatives
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