Clinical impact of mitral calcium volume in patients undergoing transcatheter aortic valve implantation

• Published in: Journal of cardiovascular computed tomography 2021-07, Vol.15 (4), p.356-365
• Main Authors: Okuno, Taishi, Brugger, Nicolas, Asami, Masahiko, Heg, Dik, Siontis, George C.M., Winkel, Mirjam G., Lanz, Jonas, Gräni, Christoph, Huber, Adrian, Stortecky, Stefan, George, Isaac, Kodali, Susheel, Pilgrim, Thomas, Windecker, Stephan, Khalique, Omar K., Praz, Fabien
• Format: Article
• Language: English
• Subjects: Aortic stenosis; Mitral annular calcification; Mitral regurgitation; Mitral stenosis; Mitral valve; Transcatheter aortic valve implantation
• ISSN: 1934-5925; 1876-861X
• DOI: 10.1016/j.jcct.2020.10.003

Mitral annular calcification (MAC) has been associated with mitral valve (MV) disease and cardiovascular events in patients undergoing transcatheter aortic valve implantation (TAVI). We aimed to investigate the incidence and impact of mitral calcium volume (MCV) quantified by multidetector computed tomography (MDCT) on MV function and clinical outcomes after TAVI. Consecutive patients with exploitable echocardiography and MDCT performed during TAVI screening were enrolled in this retrospective analysis. Mitral calcium was assessed visually and measured using a semi-automatic tool developed for the aortic valve in an off-label fashion. MCV >0 mm3 was found in 65% of the 875 included patients. Patients with calcification were older (82 ± 6 versus 81 ± 7; P = 0.002) and had high prevalence of renal dysfunction (69% versus 61%; P = 0.017) and mitral stenosis (25% versus 4%, P