Oculomotor nerve palsy in pituitary apoplexy associated with pituitary adenoma: a radiological analysis with fast imaging employing with steady-state acquisition

• Published in: Acta neurochirurgica 2021-02, Vol.163 (2), p.383-389
• Main Authors: Sasagawa, Yasuo, Aburano, Hiroyuki, Ooiso, Kazumasa, Oishi, Masahiro, Hayashi, Yasuhiko, Nakada, Mitsutoshi
• Format: Article
• Language: English
• Subjects: Adenoma; Chiropractic medicine; Compression; Interventional Radiology; Medicine; Medicine & Public Health; Minimally Invasive Surgery; Nerves; Neurological disorders; Neurology; Neuroradiology; Neurosurgery; Oculomotor nerve; Original Article - Pituitaries; Paralysis; Pituitaries; Pituitary; Sinuses; Surgical Orthopedics; Tumors
• ISSN: 0001-6268; 0942-0940
• DOI: 10.1007/s00701-020-04632-y

Purpose Oculomotor nerve palsy (ONP) occasionally occurs in cases of pituitary apoplexy (PA) associated with pituitary adenoma, but its mechanism remains unclear. Intracranial nerves are clearly visualized by fast-imaging employing with steady-state acquisition (FIESTA). Here, we assessed the oculomotor nerve compression in patients with PA associated with pituitary adenoma using FIESTA. Methods Twenty-eight cases of PA, with or without ONP, were retrospectively reviewed. All patients had undergone preoperative FIESTA. Two neuroradiologists, unaware of the patient’s clinical symptoms, evaluated the presence and location of oculomotor nerve compression due to the tumor. Results Thirteen of the twenty-eight PA cases were associated with ONP. Tumor size and degree of cavernous sinus invasion were not significantly different between the ONP and non-ONP groups. Even in the ONP group, 8/13 (62%) tumors did not show cavernous sinus invasion. Via FIESTA, the presence of oculomotor nerve compression was confirmed in 11/13 (85%) and 5/15 (33%) cases in the ONP and non-ONP groups, respectively ( p = 0.008). The radiologists’ diagnoses of laterality of nerve compression (right or left) were consistent with the patient’s affected eye. In the ONP group, the location of the nerve compression was located at the entry point to the cavernous sinus, the so-called oculomotor triangle, in 9/11 (82%) cases and intra cavernous sinus in 2/11 (18%) cases. Conclusion Compression at the oculomotor triangle is considered the main cause of ONP with PA in pituitary adenomas.