Interleukin 8 may predict surgical necrotizing enterocolitis in infants born less than 1500 g

•IL-8 measured within 72 hrs of life was significantly elevated in the surgical NEC infants.•IL-10 measured within 72 hrs of life was significantly higher in the NEC/FI group.•Cytokines can predict the severity of NEC. Necrotizing enterocolitis (NEC) often leads to gastrointestinal emergency resulti...

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Bibliographic Details
Published in:Cytokine (Philadelphia, Pa.) Pa.), 2021-01, Vol.137, p.155343-155343, Article 155343
Main Authors: Seo, Yu-mi, Lin, Yen-Kuang, Im, Soo-Ah, Sung, In-Kyung, Youn, Young-Ah
Format: Article
Language:English
Subjects:
Biomarkers - blood
Cytokines
Cytokines - blood
Enterocolitis, necrotizing
Enterocolitis, Necrotizing - blood
Enterocolitis, Necrotizing - diagnosis
Enterocolitis, Necrotizing - surgery
Feeding intolerance
Gestational Age
Humans
IL-8, IL-10
Infant
Infant, Newborn
Infant, Premature - blood
Infant, Premature, Diseases - blood
Infant, Premature, Diseases - diagnosis
Infant, Premature, Diseases - surgery
Infant, Very Low Birth Weight - blood
Inflammation Mediators - blood
Interleukin-10 - blood
Interleukin-8 - blood
Prognosis
Prospective Studies
Very low birth weight infants
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Summary:•IL-8 measured within 72 hrs of life was significantly elevated in the surgical NEC infants.•IL-10 measured within 72 hrs of life was significantly higher in the NEC/FI group.•Cytokines can predict the severity of NEC. Necrotizing enterocolitis (NEC) often leads to gastrointestinal emergency resulting high mortality in very low birth weight infants (VLBWIs) requiring surgery. To date, few studies have explored the role of serum cytokines in the development of feeding intolerance (FI) or NEC outcomes in VLBWIs. Infants born weighing
ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2020.155343