Expression of Protein Kinases RIPK-1 and RIPK-3 in Mouse and Human Hair Follicle

Expression of cell death regulators RIPK-1 and RIPK-3 in mouse and human hair follicle structures was studied by immunohistochemistry. At anagen and catagen stages of mouse hair follicle, RIPK-1+ cells were located in the inner root sheath, whereas RIPK-3+ cells were found in the inner and outer roo...

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Published in:Doklady. Biochemistry and biophysics 2020-09, Vol.494 (1), p.252-255
Main Authors: Morgun, E. I., Pozdniakova, E. D., Vorotelyak, E. A.
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Apoptosis - physiology
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Cell death
Epidermis
Hair Follicle - growth & development
Hair Follicle - metabolism
Humans
Immunohistochemistry
Immunohistochemistry - methods
Life Sciences
Male
Mice
Mice, Inbred C57BL
Molecular Biology
Necroptosis
Protein kinase
Receptor-Interacting Protein Serine-Threonine Kinases - metabolism
Skin - growth & development
Skin - metabolism
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Summary:Expression of cell death regulators RIPK-1 and RIPK-3 in mouse and human hair follicle structures was studied by immunohistochemistry. At anagen and catagen stages of mouse hair follicle, RIPK-1+ cells were located in the inner root sheath, whereas RIPK-3+ cells were found in the inner and outer root sheath, dermal papilla, and interfollicular epidermis. RIPK-1 expression intensity was low in the early anagen and increased as mature anagen and catagen approached. RIPK-1+ and RIPK-3+ cells were also found in human hair follicle. It is assumed that the role of necroptosis markers in hair follicle life activity is independent of programmed cell death and that they may have yet unknown functions and take part in noncanonical signal cascades.
ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672920050105