Histopathologic findings of idiopathic trachyonychia: An analysis of 30 adult patients

Background Trachyonychia, a rare inflammatory disease of the nail matrix, has a more chronic course in adults compared with that in children. However, the histopathologic features of the disease have not been sufficiently reported in the literature. Methods We retrospectively reviewed the pathologic...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cutaneous pathology 2021-03, Vol.48 (3), p.396-402
Main Authors: Hur, Keunyoung, Han, Byeol, Lim, Sophie Soyeon, Mun, Je‐Ho
Format: Article
Language:English
Subjects:
Degeneration
Exocytosis
histopathology
Hyperplasia
Infiltration
Inflammation
Inflammatory diseases
Leukocytes (eosinophilic)
Leukocytes (neutrophilic)
nail disorder
pathology
Statistical analysis
Stratum corneum
trachyonychia
twenty‐nail dystrophy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Trachyonychia, a rare inflammatory disease of the nail matrix, has a more chronic course in adults compared with that in children. However, the histopathologic features of the disease have not been sufficiently reported in the literature. Methods We retrospectively reviewed the pathologic features of idiopathic trachyonychia in adult cases at our center. Results A total of 30 cases were included. The median age was 55.5 years (range, 27‐77 years). Median disease duration was 84 months (range, 8‐384 months). Histopathologic analysis showed upper dermal lymphocytic infiltrates (93.3%), acanthosis (86.7%), exocytosis (63.3%), spongiosis (63.3%), parakeratosis (46.7%), psoriasiform hyperplasia (40%), eosinophilic infiltrates (33.3%), vacuolar degeneration (33.3%), lichenoid pattern (13.3%), Civatte body (6.7%), and collection of neutrophils in the stratum corneum (3.3%). Statistical analysis among pathologic parameters revealed associations of spongiosis with exocytosis (P 
ISSN:0303-6987
1600-0560
DOI:10.1111/cup.13909