Efficacy, safety, and user experience of DIY or open-source artificial pancreas systems: a systematic review

The do-it-yourself artificial pancreas system (DIYAPS) is a patient-driven initiative with the potential to revolutionise diabetes management, automating insulin delivery with existing pumps and CGM combined with open-source algorithms. Given the considerable interest in this topic within the diabet...

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Bibliographic Details
Published in:Acta diabetologica 2021-05, Vol.58 (5), p.539-547
Main Authors: Asarani, N. A. M., Reynolds, A. N., Elbalshy, M., Burnside, M., de Bock, M., Lewis, D. M., Wheeler, B. J.
Format: Article
Language:English
Subjects:
Clinical trials
Diabetes
Diabetes mellitus
Hemoglobin
Hypoglycemia
Insulin
Internal Medicine
Medicine
Medicine & Public Health
Metabolic Diseases
Pancreas
Quality of life
Review Article
Systematic review
User experience
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Summary:The do-it-yourself artificial pancreas system (DIYAPS) is a patient-driven initiative with the potential to revolutionise diabetes management, automating insulin delivery with existing pumps and CGM combined with open-source algorithms. Given the considerable interest in this topic within the diabetes community, we have conducted a systematic review of DIYAPS efficacy, safety, and user experience. Following recognised procedures and reporting standards, we identified 10 eligible publications of 730 participants within the peer-reviewed literature. Overall, studies reported improvements in time in range, HbA1c (glycated haemoglobin), reduced hypoglycaemia, and improved quality of life with DIYAPS use. While results were positive, the identified studies were small, and the majority were observational and at high risk of bias. Further research including well-designed randomised trials comparing DIYAPS with appropriate comparators is recommended.
ISSN:0940-5429
1432-5233
DOI:10.1007/s00592-020-01623-4