Cardioprotection of pharmacological postconditioning on myocardial ischemia/reperfusion injury

Acute myocardial infarction is associated with high rates of morbidity and mortality and can cause irreversible myocardial damage. Timely reperfusion is critical to limit infarct size and salvage the ischemic myocardium. However, reperfusion may exacerbate lethal tissue injury, a phenomenon known as...

Full description

Saved in:
Bibliographic Details
Published in:Life sciences (1973) 2021-01, Vol.264, p.118628-118628, Article 118628
Main Authors: Wu, Yushi, Liu, Haiqiong, Wang, Xianbao
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - therapeutic use
Antioxidants - metabolism
Apoptosis
Autophagy
Calcium - metabolism
Cardioprotection
Cardiotonic Agents - therapeutic use
Clinical Trials as Topic
Endoplasmic Reticulum - metabolism
Endoplasmic Reticulum Stress
HMGB1 Protein - metabolism
Humans
Inflammation
Injuries
Ischemia
Ischemic Postconditioning - methods
Ischemic Preconditioning, Myocardial
Mechanisms
Morbidity
Myocardial infarction
Myocardial ischemia
Myocardial Ischemia - physiopathology
Myocardial ischemia/reperfusion injury
Myocardial Reperfusion Injury - prevention & control
Myocardium
Pharmacological postconditioning
Pharmacology
Preconditioning
Reactive Oxygen Species - metabolism
Reperfusion
Reperfusion Injury
Signal Transduction
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Acute myocardial infarction is associated with high rates of morbidity and mortality and can cause irreversible myocardial damage. Timely reperfusion is critical to limit infarct size and salvage the ischemic myocardium. However, reperfusion may exacerbate lethal tissue injury, a phenomenon known as myocardial ischemia/reperfusion (I/R) injury. Pharmacological postconditioning (PPC), a strategy involving medication administration before or during the early minutes of reperfusion, is more efficient and flexible than preconditioning or ischemic conditioning. Previous studies have shown that various mechanisms are involved in the effects of PPC. In this review, we summarize the relative effects and potential underlying mechanisms of PPC to provide a foundation for future research attempting to develop novel treatments against myocardial I/R injury.
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2020.118628