The effect of a duodenal-jejunal bypass liner on lipid profile and blood concentrations of long chain polyunsaturated fatty acids

• Published in: Clinical nutrition (Edinburgh, Scotland) Scotland), 2021-04, Vol.40 (4), p.2343-2354
• Main Authors: Glaysher, Michael A., Ward, James, Aldhwayan, Madhawi, Ruban, Aruchuna, Prechtl, Christina Gabriele, Fisk, Helena L., Chhina, Navpreet, Al-Najim, Werd, Smith, Claire, Klimowska-Nassar, Natalia, Johnson, Nicholas, Falaschetti, Emmanuela, Goldstone, Anthony P., Miras, Alexander Dimitri, Byrne, James P., Calder, Philip C., Teare, Julian P.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Bariatric Surgery; Body Mass Index; Cholesterol - blood; Cholesterol, LDL - blood; Duodenal-jejunal bypass liner; Duodenum - surgery; Endobarrier; Endoscopic bariatric therapies; Fatty Acids, Unsaturated - blood; Female; Humans; Jejunum - surgery; Lipids; Male; Middle Aged; Obesity; Obesity, Morbid - surgery; Polyunsaturated fatty acids; Prostheses and Implants; Treatment Outcome; Weight Loss; Young Adult
• ISSN: 0261-5614; 1532-1983
• DOI: 10.1016/j.clnu.2020.10.026

Duodenal-jejunal bypass liners (DJBLs) prevent absorption in the proximal small intestine, the site of fatty acid absorption. We sought to investigate the effects of a DJBL on blood concentrations of essential fatty acids (EFAs) and bioactive polyunsaturated fatty acids (PUFAs). Sub-study of a multicentre, randomised, controlled trial with two treatment groups. Patients aged 18–65 years with type-2 diabetes mellitus and body mass index 30–50 kg/m2 were randomised to receive a DJBL for 12 months or best medical therapy, diet and exercise. Whole plasma PUFA concentrations were determined at baseline, 10 days, 6 and 11.5 months; data were available for n = 70 patients per group. Weight loss was significantly greater in the DJBL group compared to controls after 11.5 months: total body weight loss 11.3 ± 5.3% versus 6.0 ± 5.7% (mean difference [95% CI] = 5.27% [3.75, 6.80], p