Mucous Membrane Pemphigoid of the Anal Canal Resulting in Anal Stricture

• Published in: The American surgeon 2023-01, Vol.89 (1), p.157-159
• Main Authors: Chapman, Brandon C., Goddard, Allison L., Schmitt, Colleen M., Mohr, Melinda R., Dozier, Tracy M., Nelson, Eric C.
• Format: Article
• Language: English
• Subjects: Airway management; Anal Canal; Anorectal; Antibodies; Anus; Anus Diseases; Autoantibodies; Biopsy; Blistering; Case reports; Colorectal surgery; Complications; Dermatology; Diagnosis; Differential diagnosis; Enzyme-linked immunosorbent assay; Esophagus; Health services; Humans; Immunofluorescence; Inflammation; Laminin; Malignancy; Medical screening; Medical treatment; Membranes; Morbidity; Mucosa; Mucous Membrane; Mucous membrane pemphigoid; Patients; Pemphigoid, Benign Mucous Membrane; Remission (Medicine); Risk; Signs and symptoms; Skin; Skin diseases; Steroids
• ISSN: 0003-1348; 1555-9823
• DOI: 10.1177/0003134820952382

Given the relative rare nature of MMP and the lack of literature specific to anorectal involvement, there may be a deficit of awareness in the medical community as well. [...]this case report is an opportunity for clinicians to highlight anorectal symptoms and treatment options for patients with a known diagnosis of pemphigoid to minimize morbidity. Additionally, a serum specimen for indirect immunofluorescence and enzyme-linked immunosorbent assay to detect circulating basement membrane zone antibodies may narrow the differential diagnosis and identify patients with autoantibodies to laminin 332 (previously known as laminin 5 and epiligrin) who are at higher risk for malignancy. 2 The primary goals of the treatment of MMP are to halt the progression of the disease, improve symptoms, and prevent adverse sequelae of chronic tissue inflammation and scarring. 2 In 2002, the First International Consensus on MMP, were published providing guidance on medical therapy for MMP. 3 Patients are categorized as high risk (ocular, genital, nasopharyngeal, esophageal, and laryngeal mucosa) or low risk (confined to the oral mucosa or oral mucosa and skin). [...]MMP is a chronic, blistering disease of the skin and mucous membranes.