Development of a high-strength Zn-Mn-Mg alloy for ligament reconstruction fixation

Although various biodegradable materials have been investigated for ligament reconstruction fixation in the past decades, only few of them possess a combination of high mechanical properties, appropriate degradation rate, good biocompatibility, and osteogenic effect, thus limiting their clinical app...

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Bibliographic Details
Published in:Acta biomaterialia 2021-01, Vol.119, p.485-498
Main Authors: Sun, Jiang, Zhang, Xin, Shi, Zhang-Zhi, Gao, Xi-Xian, Li, Hui-Yan, Zhao, Feng-Yuan, Wang, Jian-Quan, Wang, Lu-Ning
Format: Article
Language:English
Subjects:
ACL reconstruction
Alloys - pharmacology
Animals
Anterior cruciate ligament
Anterior Cruciate Ligament - surgery
Anterior Cruciate Ligament Reconstruction
Biocompatibility
Biodegradability
Biodegradable materials
Biodegradation
Biomechanical Phenomena
Biomedical materials
Bone growth
Bone Screws
Degradation
Fixation
High strength alloys
Interference screw
Knee
Ligaments
Magnesium base alloys
Manganese
Mechanical properties
Mineralization
Peri-tunnel bone loss
Rabbits
Rehabilitation
Screws
Soft tissues
Tendon-bone integration
Titanium base alloys
Zinc
Zn alloy
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Summary:Although various biodegradable materials have been investigated for ligament reconstruction fixation in the past decades, only few of them possess a combination of high mechanical properties, appropriate degradation rate, good biocompatibility, and osteogenic effect, thus limiting their clinical applications. A high-strength Zn-0.8Mn-0.4Mg alloy (i.e., Zn08Mn04Mg) with yield strength of 317 MPa was developed to address this issue. The alloy showed good biocompatibility and promising osteogenic effect in vitro. The degradation effects of Zn08Mn04Mg interference screws on the interface between soft tissue and bone were investigated in anterior cruciate ligament (ACL) reconstruction in rabbits. Compared to Ti6Al4V, the Zn alloy screws significantly accelerated the formation of new bone and further induced partial tendon mineralization, which promoted tendon-bone integration. The newly developed screws are believed to facilitate early joint function recovery and rehabilitation training and also avoid screw breakage during insertion, thereby contributing to an extensive clinical prospect. [Display omitted]
ISSN:1742-7061
1878-7568
DOI:10.1016/j.actbio.2020.10.032