Rubellawus A–D, Four New Diterpenoids Isolated from Callicarpa rubella and Their Anti‐NLRP3 Inflammasome Effects

Four new diterpenoids, rubellawus A–D (1–4), along with three known compounds, were isolated and identified from the flowers of Callicarpa rubella. Their structures were elucidated by various spectroscopic analysis. All the compounds were screened for their anti‐inflammatory activity and 14α‐hydroxy...

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Published in:Chemistry & biodiversity 2020-12, Vol.17 (12), p.e2000798-n/a
Main Authors: Wu, Xue‐Wen, Wang, Qi, Li, Qing, Cui, Yi‐Man, Pu, Yu‐Kun, Shi, Qiang‐Qiang, Bi, De‐Wen, Zhang, Jing‐Jing, Zhang, Rui‐Han, Li, Xiao‐Li, Zhang, Xing‐Jie, Xiao, Wei‐Lie
Format: Article
Language:English
Subjects:
anti-inflammatory activity
Callicarpa
Callicarpa rubella
Diterpenes
diterpenoids
Flowers
Inflammasomes
Inflammation
Isopimaric acid
NLRP3 inflammasome
Rubella
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container_title Chemistry & biodiversity
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creator Wu, Xue‐Wen
Wang, Qi
Li, Qing
Cui, Yi‐Man
Pu, Yu‐Kun
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Bi, De‐Wen
Zhang, Jing‐Jing
Zhang, Rui‐Han
Li, Xiao‐Li
Zhang, Xing‐Jie
Xiao, Wei‐Lie
description Four new diterpenoids, rubellawus A–D (1–4), along with three known compounds, were isolated and identified from the flowers of Callicarpa rubella. Their structures were elucidated by various spectroscopic analysis. All the compounds were screened for their anti‐inflammatory activity and 14α‐hydroxyisopimaric acid and isopimaric acid showed significant NLRP3 inflammasome inhibitory activity with IC50 values of 7.02 and 3.99 μM.
doi_str_mv 10.1002/cbdv.202000798
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source Wiley-Blackwell Read & Publish Collection
subjects anti-inflammatory activity
Callicarpa
Callicarpa rubella
Diterpenes
diterpenoids
Flowers
Inflammasomes
Inflammation
Isopimaric acid
NLRP3 inflammasome
Rubella
title Rubellawus A–D, Four New Diterpenoids Isolated from Callicarpa rubella and Their Anti‐NLRP3 Inflammasome Effects
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