Mapping genes for phosphorus utilization and correlated traits using a 4k SNP linkage map in Japanese quail (Coturnix japonica)

Summary A large F2 cross with 920 Japanese quail was used to map QTL for phosphorus utilization, calcium utilization, feed per gain and body weight gain. In addition, four bone ash traits were included, because it is known that they are genetically correlated with the focal trait of phosphorus utili...

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Bibliographic Details
Published in:Animal genetics 2021-02, Vol.52 (1), p.90-98
Main Authors: Vollmar, S., Haas, V., Schmid, M., Preuß, S., Joshi, R., Rodehutscord, M., Bennewitz, J.
Format: Article
Language:English
Subjects:
Body weight
Body weight gain
Calcium
Chromosomes
Correlation
feed utilization
Gene mapping
Genes
Genomes
Japanese quail
linkage map
Mapping
Phosphorus
Polygenic inheritance
Quantitative trait loci
Regression analysis
Single-nucleotide polymorphism
Utilization
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Summary:Summary A large F2 cross with 920 Japanese quail was used to map QTL for phosphorus utilization, calcium utilization, feed per gain and body weight gain. In addition, four bone ash traits were included, because it is known that they are genetically correlated with the focal trait of phosphorus utilization. Trait recording was done at the juvenile stage of the birds. The individuals were genotyped genome‐wide for about 4k SNPs and a linkage map constructed, which agreed well with the reference genome. QTL linkage mapping was performed using multimarker regression analysis in a line cross model. Single marker association mapping was done within the mapped QTL regions. The results revealed several genome‐wide significant QTL. For the focal trait phosphorus utilization, a QTL on chromosome CJA3 could be detected by linkage mapping, which was substantiated by the results of the SNP association mapping. Four candidate genes were identified for this QTL, which should be investigated in future functional studies. Some overlap of QTL regions for different traits was detected, which is in agreement with the corresponding genetic correlations. It seems that all traits investigated are polygenic in nature with some significant QTL and probably many other small‐effect QTL that were not detectable in this study.
ISSN:0268-9146
1365-2052
DOI:10.1111/age.13018