IgA vasculitis in a patient with ulcerative colitis under infliximab: drug-induced or genetic?

We present the case of a 17-year-old male patient with ulcerative colitis (UC) under infliximab therapy and a family history of IgA vasculitis (IgAV). During a maintenance infliximab session, he developed palpable purpura, abdominal pain, and hematochezia. Computed tomography and endoscopy revealed...

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Bibliographic Details
Published in:Clinical journal of gastroenterology 2021-02, Vol.14 (1), p.198-203
Main Authors: Urushikubo, Jun, Yanai, Shunichi, Nakamura, Shotaro, Toya, Yosuke, Asakura, Kensuke, Gonai, Takahiro, Eizuka, Makoto, Uesugi, Noriyuki, Sugai, Tamotsu, Matsumoto, Takayuki
Format: Article
Language:English
Subjects:
Abdominal Surgery
Case Report
Colorectal Surgery
Gastroenterology
Hepatology
Medicine
Medicine & Public Health
Surgical Oncology
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Summary:We present the case of a 17-year-old male patient with ulcerative colitis (UC) under infliximab therapy and a family history of IgA vasculitis (IgAV). During a maintenance infliximab session, he developed palpable purpura, abdominal pain, and hematochezia. Computed tomography and endoscopy revealed findings compatible with gastrointestinal manifestations of IgAV. He was successfully treated by intravenous prednisolone and did not develop recurrence of IgAV during subsequent infliximab infusions.
ISSN:1865-7257
1865-7265
DOI:10.1007/s12328-020-01280-8