A Comparison of Triamcinolone Acetonide Econazole Cream and Nystatin Suspension in Treatment of Otomycosis

• Published in: The Laryngoscope 2021-05, Vol.131 (5), p.E1640-E1646
• Main Authors: Chen, Qingguo, Chu, Hanqi, Tao, Yanling, Peng, Liyan, Zhou, Liangqiang, Liu, Lei, Wu, Xiaohui
• Format: Article
• Language: English
• Subjects: Administration, Topical; Adolescent; Adult; adverse effect; Aged; Aged, 80 and over; Antifungal agents; Antifungal Agents - administration & dosage; Antifungal Agents - adverse effects; Aspergillosis - diagnosis; Aspergillosis - drug therapy; Aspergillosis - microbiology; Aspergillus niger - isolation & purification; Child; Child, Preschool; Dermatitis, Irritant - epidemiology; Dermatitis, Irritant - etiology; Drug Combinations; Ear Canal - drug effects; Ear Canal - microbiology; Earache - chemically induced; Earache - epidemiology; Ears & hearing; Econazole - administration & dosage; Econazole - adverse effects; efficacy; Female; Fungal infections; Headache - chemically induced; Headache - epidemiology; Humans; Infant; Laryngoscopy; Male; Medical treatment; Middle Aged; nystatin; Nystatin - administration & dosage; Nystatin - adverse effects; Otomycosis; Otomycosis - drug therapy; Otomycosis - microbiology; Prospective Studies; Suspensions; Treatment Outcome; Triamcinolone Acetonide - administration & dosage; Triamcinolone Acetonide - adverse effects; triamcinolone acetonide econazole cream; Young Adult
• ISSN: 0023-852X; 1531-4995
• DOI: 10.1002/lary.29190

Objectives/Hypothesis To compare the efficacy and adverse effects of triamcinolone acetonide econazole cream and nystatin suspension in the treatment of otomycosis, and to determine the clinical features, predisposing factors, and etiology of otomycosis. Study Design A prospective study. Methods A prospective clinical trial was conducted on 786 patients diagnosed with otomycosis. The study population was randomly divided into two treatment groups of triamcinolone acetonide econazole cream (TAEC) and nystatin suspension in a 1:1 ratio. After clearing all fungal deposits in the external auditory canal, the antimycotic drugs were locally applied for at least 2 weeks. The efficacy and adverse effects were compared between the two antifungal reagents by statistical analysis. Meanwhile, patient clinical data were collected to find out the clinical features, predisposing factors, and etiology. Results Pruritis was the most common symptom and Aspergillus niger was the leading fungal pathogen. There was high association (44.5%) of otomycosis with a history of unclean ear picking. The cure rate was 97.6% in the TAEC group and 73.5% in the nystatin group (P