Need for Vitreous Surgeries in Proliferative Diabetic Retinopathy in 10-Year Follow-Up: India Retinal Disease Study Group Report No. 2

Introduction: To report the 10-year rate of vitrectomies and the associated factors in people with proliferative diabetic retinopathy (PDR) from a multicentric cohort of people with diabetes mellitus. Methods: Ten centres in India with established vitreoretinal (VR) services for over 10 years were i...

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Published in:Ophthalmic research 2021-06, Vol.64 (3), p.432-439
Main Authors: Khan, Rehana, Surya, Janani, Rajalakshmi, Ramachandran, Rani, Padmaja Kumari, Anantharaman, Giridhar, Gopalakrishnan, Mahesh, Sen, Alok, Desai, Abhishek, Roy, Rupak, Natarajan, Sundaram, Chen, Lanin, Chawla, Gajendra, Behera, Umesh Chandra, Gopal, Lingam, Muralidharan, Vinata, Sivaprasad, Sobha, Raman, Rajiv
Format: Article
Language:English
Subjects:
Cataract
Diabetic retinopathy
Diabetics
Medical research
Medicine, Experimental
Research Article
Surgery
Vascular endothelial growth factor
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Summary:Introduction: To report the 10-year rate of vitrectomies and the associated factors in people with proliferative diabetic retinopathy (PDR) from a multicentric cohort of people with diabetes mellitus. Methods: Ten centres in India with established vitreoretinal (VR) services for over 10 years were invited to provide long-term data on PDR. People with Type 1 or 2 diabetes with a clinical diagnosis of active PDR in 1 or both eyes were included. Baseline data collected included age, sex, duration of diabetes, source of referral and best-corrected visual acuity, and diabetic retinopathy status in both eyes. Available follow-up data included the numbers of panretinal photocoagulation (PRP) sessions, cataract surgery, treatment of diabetic macular oedema, use of anti-vascular endothelial growth factor (VEGF) therapy, vitrectomy with or without retinal surgeries over 10 years. Results: Over 10 years, 89% needed supplemental PRP after initial complete PRP. One-third required retinal surgery, 16% needed intravitreal injection. Men (74.5%) had significant higher risk for vitreous (VR) surgery. Of the group with low-risk PDR, 56.8% did not require VR surgery, p < 0.001. Of the patients who underwent cataract surgery and had intravitreal anti-VEGF injections, 78.5 and 28.2% needed subsequent vitreous (VR) surgery, p = 0.006 and
ISSN:0030-3747
1423-0259
DOI:10.1159/000512767