Arterial stiffness measured by cardio‐ankle vascular index is greater in non‐obese young women with polycystic ovarian syndrome

• Published in: The journal of obstetrics and gynaecology research 2021-02, Vol.47 (2), p.521-528
• Main Authors: Kilic, Derya, Kilic, Ismail Dogu, Sevgican, Cihan Ilyas, Kilic, Oguz, Alatas, Erkan, Arslan, Muhammet, Avci, Esin, Guler, Tolga
• Format: Article
• Language: English
• Subjects: Androgens; Ankle; Body mass index; cardiovascular disease; Cardiovascular diseases; Multiple regression analysis; ovarian function/menstrual disorders; Ovaries; Polycystic ovary syndrome; polycystic ovary syndrome/hyperandrogenism
• ISSN: 1341-8076; 1447-0756
• DOI: 10.1111/jog.14543

Aim The association of metabolic abnormalities and polycystic ovarian syndrome (PCOS) has been documented, but few studies have focused on cardiovascular risk in these women. The aim of this study was to compare arterial stiffness by using the cardio‐ankle vascular index (CAVI) in PCOS women with controls, and to evaluate whether any clinical or laboratory variables had independent associations with it. Methods A group of 160 women, matched for age and body mass index were recruited. Diagnosis of PCOS was made according to the Rotterdam criteria. Arterial stiffness using CAVI was evaluated in non‐obese young woman, with and without PCOS. Results In the PCOS group (n = 80), 60 cases (75%) had findings of hyperandrogenism, 59 (73.8%) had ovulatory dysfunction, and 70 (87.5%) had an ultrasonographic appearance of polycystic ovaries. Women with PCOS had significantly higher mean CAVI values when compared to subjects without PCOS (5.78 ± 0.64 vs 5.28 ± 0.77, P