Two new compounds with anti-inflammatory activity from Alangium chinense

A new phenolic glycoside, chinenside A (1), and a new megastigmane glycoside, chinenionside A (2), together with twelve known compounds (3-14), were isolated from the roots of Alangium chinense. Their structures were deduced on the basis of extensive spectroscopic analyses and comparison with data r...

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Bibliographic Details
Published in:Natural product research 2022-02, Vol.36 (4), p.891-895
Main Authors: Yue, Yue-Dong, Xiang, Zhi-Nan, Chen, Jia-Chun
Format: Article
Language:English
Subjects:
Alangiaceae - chemistry
Alangium chinense
Animals
anti-inflammatory activity
Anti-inflammatory agents
Anti-Inflammatory Agents - pharmacology
Glycosides
Glycosides - chemistry
IL-1β
Inflammation
Interleukin 1
Interleukin 6
Lipopolysaccharides
Lipopolysaccharides - pharmacology
Macrophages
megastigmane glycoside
Mice
Nitric Oxide
Phenolic compounds
phenolic glycoside
Phenols
RAW 264.7 Cells
Triptolide
Tumor Necrosis Factor-alpha
Tumor necrosis factor-α
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Summary:A new phenolic glycoside, chinenside A (1), and a new megastigmane glycoside, chinenionside A (2), together with twelve known compounds (3-14), were isolated from the roots of Alangium chinense. Their structures were deduced on the basis of extensive spectroscopic analyses and comparison with data reported in the literature. The anti-inflammatory activity in vitro of all 13 phenolic glycosides was evaluated against lipopolysaccharide-induced mouse macrophage RAW264.7 cells. The compounds 1, 9, and 10 potentially inhibited the productions of nitric oxide (NO), prostaglandin (PEG 2 ), tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β) and interleukin 6 (IL-6). Compound 1 (50 μM) showed stronger anti-inflammatory activity than Triptolide (TPL, 20 nm).
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2020.1843033