Diagnostic utility of fine needle aspiration cytology and core biopsy histopathology with or without immunohistochemical staining in the subtyping of the non‐small cell lung carcinomas: Experience from an academic centre in Turkey

• Published in: Cytopathology (Oxford) 2021-05, Vol.32 (3), p.331-337
• Main Authors: Bayrak, Büşra Yaprak, Paksoy, Nadir, Vural, Çiğdem
• Format: Article
• Language: English
• Subjects: Adenocarcinoma; Adenocarcinoma - diagnosis; Adenocarcinoma - pathology; Adult; Aged; Aged, 80 and over; Biopsy; Biopsy, Fine-Needle - methods; Biopsy, Large-Core Needle - methods; Carcinoma, Non-Small-Cell Lung - diagnosis; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Squamous Cell - diagnosis; Carcinoma, Squamous Cell - pathology; Cellular biology; Computed tomography; core needle biopsy; Cytology; Diagnosis; diagnostic utility; Female; fine needle aspiration cytology; Histology; Humans; immunohistochemistry; Immunohistochemistry - methods; Lung carcinoma; Lung Neoplasms - diagnosis; Lung Neoplasms - pathology; Male; Middle Aged; Non-small cell lung carcinoma; non‐small cell lung carcinoma subtyping; Retrospective Studies; Small cell lung carcinoma; Squamous cell carcinoma; Staining and Labeling - methods; Turkey
• ISSN: 0956-5507; 1365-2303
• DOI: 10.1111/cyt.12937

Introduction This retrospective morphological study compared the results of fine needle aspiration (FNA) cytology, haematoxylin‐eosin (HE)‐stained samples and immunohistochemical (IHC)‐stained core needle biopsy (CNB) histology samples for primary non‐small cell lung cancer (NSCLC) subtyping. We assessed the diagnostic utility of these methods to investigate the contribution of each method to NSCLC subtyping. We also identified the point at which NSCLC subtyping could be performed using histomorphology alone without IHC. Methodology Concurrent FNA and CNB specimens obtained via a single computed tomography‐guided procedure and diagnosed as NSCLC in the Pathology Department of our university within 3 years were reviewed. The results of FNA samples, HE‐stained biopsies and IHC‐stained biopsies were compared according to subtype. Results A total of 141 subjects were enrolled in the study. For subtyping, FNA provided an accurate diagnosis in 70 (55.1%) of 127 eligible subjects after the exclusion of 14 cases determined as not otherwise specified. CNB histology without IHC achieved a diagnosis in 53 (41.7%) of 127 subjects, which was a significant difference (P