Recent advances in light-induced cell sheet technology

Various stimuli have been applied to harvest complete cell sheets, including temperature, magnetic, pH, and electrical stimuli. Cell sheet technology is a convenient and efficient approach with beneficial effects for tissue regeneration and cell therapy. Lights of different wavelengths, such as ultr...

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Bibliographic Details
Published in:Acta biomaterialia 2021-01, Vol.119, p.30-41
Main Authors: Jiang, Zhiwei, Zhu, Danji, Yu, Ke, Xi, Yue, Wang, Xiaozhao, Yang, Guoli
Format: Article
Language:English
Subjects:
Cell adhesion
Cell detachment
Cell sheet
Cell therapy
Collagen
Electrical stimuli
Illumination
Infrared radiation
Irradiation
Light
Light-induced
Material surface
Moisture content
Regeneration
Stimuli
Technology
Temperature
Tissue engineering
Ultraviolet radiation
Ultraviolet Rays
Water content
Wavelengths
Wettability
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Summary:Various stimuli have been applied to harvest complete cell sheets, including temperature, magnetic, pH, and electrical stimuli. Cell sheet technology is a convenient and efficient approach with beneficial effects for tissue regeneration and cell therapy. Lights of different wavelengths, such as ultraviolet (UV), visible light, and near infrared ray (NIR) light, were confirmed to aid in fabricating a cell sheet. Changes in the wettability, potential, or water content of the culturing surfaces that occur under light illumination induce conformational changes in the adhesive proteins or collagens, which then leads to cell sheet detachment. However, the current approaches face several limitations, as few standards for safe light illumination have been proposed to date, and require a careful control of the wavelength, power, and irradiation time. Future studies should aim at generating new materials for culturing and releasing cell sheets rapidly and effectively. [Display omitted]
ISSN:1742-7061
1878-7568
DOI:10.1016/j.actbio.2020.10.044