Transition metal catalysts for the bioorthogonal synthesis of bioactive agents

The incorporation of abiotic transition metal catalysis into the chemical biology space has significantly expanded the tool kit of bioorthogonal chemistries accessible for cell culture and in vivo applications. A rich variety of homogeneous and heterogeneous catalysts has shown functional compatibil...

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Bibliographic Details
Published in:Current opinion in chemical biology 2021-04, Vol.61, p.32-42
Main Authors: van de L'Isle, Melissa O.N., Ortega-Liebana, Mari Carmen, Unciti-Broceta, Asier
Format: Article
Language:English
Subjects:
Bioorthogonal chemistry
Heterogeneous catalysts
Homogeneous catalysts
Prodrug activation
Transition metal catalysis
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Summary:The incorporation of abiotic transition metal catalysis into the chemical biology space has significantly expanded the tool kit of bioorthogonal chemistries accessible for cell culture and in vivo applications. A rich variety of homogeneous and heterogeneous catalysts has shown functional compatibility with physiological conditions and biostability in complex environs, enabling their exploitation as extracellular or intracellular factories of bioactive agents. Current trends in the field are focusing on investigating new metals and sophisticated catalytic devices and toward more applied activities, such as the integration of subcellular, cell- and site-targeting capabilities or the exploration of novel biomedical applications. We present herein an overview of the latest advances in the field, highlighting the increasing role of transition metals for the controlled release of therapeutics. [Display omitted]
ISSN:1367-5931
1879-0402
DOI:10.1016/j.cbpa.2020.10.001