Mediation effect of C-reactive protein in the relationship between abdominal obesity and intermediate hyperglycemia in Kuwaiti adolescents

This study aimed to investigate the mediating effect of C-reactive protein (CRP) on obesity and hyperglycemia. Fasting blood glucose, high-sensitivity CRP (hs-CRP) levels and waist circumference (WC) were measured on 353 participants. Multilevel regression modeling and mediation analyses were used t...

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Bibliographic Details
Published in:Biomarkers in medicine 2020-10, Vol.14 (15), p.1427-1437
Main Authors: Alqaderi, Hend, Al-Ozairi, Ebaa, Bin-Hasan, Saadoun, Tavares, Mary, Goodson, Jo M, Alsumait, Aishah, Abu-Farha, Mohamed, Abubaker, Jehad, Devarajan, Sriraman, Almuhana, Nourah, Al-Mulla, Fahd
Format: Article
Language:English
Subjects:
Abdomen
adolescents
Blood pressure
C-reactive protein
Cardiovascular disease
Chronic illnesses
Data collection
Diabetes
Education
Fasting
Hyperglycemia
Laboratories
Obesity
prevention
Proteins
Schools
Variables
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Summary:This study aimed to investigate the mediating effect of C-reactive protein (CRP) on obesity and hyperglycemia. Fasting blood glucose, high-sensitivity CRP (hs-CRP) levels and waist circumference (WC) were measured on 353 participants. Multilevel regression modeling and mediation analyses were used to investigate the link between abdominal obesity, hs-CRP and hyperglycemia. Elevation in hs-CRP was predictive of hyperglycemia in nonobese individuals (OR = 1.3, p = 0.03). With every 1-mg/l increase in hs-CRP, there was a 1-cm increase in WC (B = 0.87, p = 0.001). hs-CRP was a full mediator in the relationship between WC and hyperglycemia. hs-CRP predicts hyperglycemia development in nonobese individuals and the effect of increased WC on hyperglycemia was fully mediated by hs-CRP.
ISSN:1752-0363
1752-0371
DOI:10.2217/bmm-2020-0282