Mediation effect of C-reactive protein in the relationship between abdominal obesity and intermediate hyperglycemia in Kuwaiti adolescents

This study aimed to investigate the mediating effect of C-reactive protein (CRP) on obesity and hyperglycemia. Fasting blood glucose, high-sensitivity CRP (hs-CRP) levels and waist circumference (WC) were measured on 353 participants. Multilevel regression modeling and mediation analyses were used t...

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Published in:Biomarkers in medicine 2020-10, Vol.14 (15), p.1427-1437
Main Authors: Alqaderi, Hend, Al-Ozairi, Ebaa, Bin-Hasan, Saadoun, Tavares, Mary, Goodson, Jo M, Alsumait, Aishah, Abu-Farha, Mohamed, Abubaker, Jehad, Devarajan, Sriraman, Almuhana, Nourah, Al-Mulla, Fahd
Format: Article
Language:English
Subjects:
Abdomen
adolescents
Blood pressure
C-reactive protein
Cardiovascular disease
Chronic illnesses
Data collection
Diabetes
Education
Fasting
Hyperglycemia
Laboratories
Obesity
prevention
Proteins
Schools
Variables
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cited_by cdi_FETCH-LOGICAL-c371t-dec8fd0fe4833568b1f8579a76cdbc55b238b14b241e47b3af99492b6c7f2d393
cites cdi_FETCH-LOGICAL-c371t-dec8fd0fe4833568b1f8579a76cdbc55b238b14b241e47b3af99492b6c7f2d393
container_end_page 1437
container_issue 15
container_start_page 1427
container_title Biomarkers in medicine
container_volume 14
creator Alqaderi, Hend
Al-Ozairi, Ebaa
Bin-Hasan, Saadoun
Tavares, Mary
Goodson, Jo M
Alsumait, Aishah
Abu-Farha, Mohamed
Abubaker, Jehad
Devarajan, Sriraman
Almuhana, Nourah
Al-Mulla, Fahd
description This study aimed to investigate the mediating effect of C-reactive protein (CRP) on obesity and hyperglycemia. Fasting blood glucose, high-sensitivity CRP (hs-CRP) levels and waist circumference (WC) were measured on 353 participants. Multilevel regression modeling and mediation analyses were used to investigate the link between abdominal obesity, hs-CRP and hyperglycemia. Elevation in hs-CRP was predictive of hyperglycemia in nonobese individuals (OR = 1.3, p = 0.03). With every 1-mg/l increase in hs-CRP, there was a 1-cm increase in WC (B = 0.87, p = 0.001). hs-CRP was a full mediator in the relationship between WC and hyperglycemia. hs-CRP predicts hyperglycemia development in nonobese individuals and the effect of increased WC on hyperglycemia was fully mediated by hs-CRP.
doi_str_mv 10.2217/bmm-2020-0282
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subjects Abdomen
adolescents
Blood pressure
C-reactive protein
Cardiovascular disease
Chronic illnesses
Data collection
Diabetes
Education
Fasting
Hyperglycemia
Laboratories
Obesity
prevention
Proteins
Schools
Variables
title Mediation effect of C-reactive protein in the relationship between abdominal obesity and intermediate hyperglycemia in Kuwaiti adolescents
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