The effect of TB treatment on health-related quality of life for people with advanced HIV

BACKGROUND: Study A5274 was an open-label trial of people with HIV (PLHIV) with CD4 cell count 13 years were enrolled from outpatient clinics in 10 countries. HRQoL was assessed at Weeks 0, 8, 24 and 96 with questions about daily activity, hospital or emergency room visits, and general health status...

Full description

Saved in:
Bibliographic Details
Published in:The international journal of tuberculosis and lung disease 2020-09, Vol.24 (9), p.910-915
Main Authors: Opollo, V., Sun, X., Lando, R., Miyahara, S., Torres, T. S., Hosseinipour, M. C., Bisson, G. P., Kumwenda, J., Gupta, A., Nyirenda, M., Katende, K., Suryavanshi, N., Beulah, F., Shah, N. S., on behalf of the A5274 study team
Format: Article
Language:English
Subjects:
Advanced Human Immunodeficiency Virus
Aged
Antiretroviral agents
Antiretroviral drugs
Antiretroviral Therapy
Antitubercular Agents - therapeutic use
CD4 antigen
Emergency medical care
Emergency medical services
Health services
HIV
HIV Infections - drug therapy
Hrqol
Human immunodeficiency virus
Humans
IPT
Isoniazid
Isoniazid - therapeutic use
Quality of Life
Signs and symptoms
Sociodemographics
Tuberculosis
Tuberculosis - drug therapy
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BACKGROUND: Study A5274 was an open-label trial of people with HIV (PLHIV) with CD4 cell count 13 years were enrolled from outpatient clinics in 10 countries. HRQoL was assessed at Weeks 0, 8, 24 and 96 with questions about daily activity, hospital or emergency room visits, and general health status. We used logistic regression to examine HRQoL by arm and association with sociodemographic and clinical factors.RESULTS: Among 850 participants (424 empiric arm, 426 IPT arm), HRQoL improved over time with no difference between arms. At baseline and Week 24, participants with WHO Stage 3 or 4 events, or those who had Grade 3 or 4 signs/symptoms, were significantly more likely to report poor HRQoL using the composite of four HRQoL measures.CONCLUSION: HRQoL improved substantially in both arms during the study period. These findings show that ART, TB screening, and IPT can not only reduce mortality, but also improve HRQoL in PLHIV with advanced disease.
ISSN:1027-3719
1815-7920
DOI:10.5588/ijtld.19.0716