Determinants of plasma fibrin clot lysis measured using three different assays in healthy subjects

Several methods for measuring fibrinolytic capacity in plasma have been developed yielding frequently inconsistent results. We investigated which factors determine fibrinolytic capacity in three plasma-based assays. In 80 apparently healthy controls (aged 43 ± 10 years, 50 women [62.5%]) we evaluate...

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Bibliographic Details
Published in:Thrombosis research 2021-01, Vol.197, p.1-7
Main Authors: Siudut, Jakub, Iwaniec, Teresa, Plens, Krzysztof, Pieters, Marlien, Undas, Anetta
Format: Article
Language:English
Subjects:
Clot lysis time
CRP
Fibrinolytic capacity
HRG
γ′-Fibrinogen
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Summary:Several methods for measuring fibrinolytic capacity in plasma have been developed yielding frequently inconsistent results. We investigated which factors determine fibrinolytic capacity in three plasma-based assays. In 80 apparently healthy controls (aged 43 ± 10 years, 50 women [62.5%]) we evaluated fibrinolysis using three assays: (1) by Pieters et al. (CLT2018), (2) by Lisman et al. (CLT), and (3) by Carter et al. (Lys50). Coagulation factors and fibrinolytic proteins, including histidine-rich glycoprotein (HRG) and γ′-fibrinogen, were determined. Regression models were performed to identify determinants of lysis times. Positive correlations were observed between CLT2018 and both CLT (r = 0.73) and Lys50 (r = 0.61), as well as between CLT and Lys50 (r = 0.46, all p 
ISSN:0049-3848
1879-2472
DOI:10.1016/j.thromres.2020.10.014