Prevalence and associated risk factors of Helicobacter pylori infection in the Wuwei cohort of north‐western China

Objectives To evaluate the prevalence of Helicobacter pylori infection and risk factors and to serotype the strains in Wuwei, located in north‐western China, which has a high incidence of gastric cancer. Methods Helicobacter pylori infection was analysed in 21 291 adults by 14C‐urea breath test, and...

Full description

Saved in:
Bibliographic Details
Published in:Tropical medicine & international health 2021-03, Vol.26 (3), p.290-300
Main Authors: Zhang, Fuhua, Pu, Ke, Wu, Zhengqi, Zhang, Zhiyi, Liu, Xin, Chen, Zhaofeng, Ye, Yuwei, Wang, Yuping, Zheng, Ya, Zhang, Jinhua, An, Feng, Zhao, Shijun, Hu, Xiaobin, Li, Youpeng, Li, Qiang, Liu, Min, Lu, Hong, Zhang, Hongling, Zhao, Yue, Yuan, Hao, Ding, Xiangping, Shu, Xiaochuang, Ren, Qian, Gou, Xi, Hu, Zenan, Wang, Jun, Wang, Yuling, Guan, Quanlin, Guo, Qinghong, Ji, Rui, Zhou, Yongning
Format: Article
Language:English
Subjects:
Antibodies
associated factors
Asthma
Cancer
Cholecystitis
Eating
Education
Fruits
Gastric cancer
Helicobacter pylori
Hypertension
Income
Infections
Latex
prevalence
Questionnaires
Risk analysis
Risk factors
serotyping
Urea
Urease
Vegetables
Wuwei cohort
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives To evaluate the prevalence of Helicobacter pylori infection and risk factors and to serotype the strains in Wuwei, located in north‐western China, which has a high incidence of gastric cancer. Methods Helicobacter pylori infection was analysed in 21 291 adults by 14C‐urea breath test, and H. pylori antibody were detected in 9183 serum samples by latex immunoturbidimetric method. The correlation of H. pylori infection with demographic–economic, lifestyle factors and medical history among the participants was determined by questionnaire. The antibodies against H. pylori urease, VacA and CagA in serum were determined by dot immunobinding assay. Results The infection rate of H. pylori was 53.0%, and 90.1% of strains were type I strains. The H. pylori infection rate was higher among farmers (OR = 1.34, 95% CI: 1.19–1.50) and individuals who had a junior high school or higher education level (OR = 1.10, 95% CI: 1.06–1.15), and was lower in older individuals (OR = 0.86, 95% CI: 0.83–0.90), individuals with high income (OR = 0.93, 95% CI: 0.90–0.95), individuals with a habit of eating quickly (OR = 0.93, 95% CI: 0.87–0.99) and individuals who consumed more fruit and vegetables (OR = 0.90, 95% CI: 0.85–0.95). Individuals with history of cholecystitis/cholecystolithiasis, hypertension and asthma were negatively correlated with H. pylori infection (P 
ISSN:1360-2276
1365-3156
DOI:10.1111/tmi.13517