Demographic, radiographic, molecular and clinical characteristics of primary gliosarcoma and differences to glioblastoma

•Gliosarcoma show a temporal lobe predilection and eccentric tumor cysts.•Patients’ age, preoperative clinical status, midline tumor location and tumor size are prognostic factors in gliosarcoma.•Gliosarcoma are associated with a poorer outcome, this difference might be linked to different genetic a...

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Bibliographic Details
Published in:Clinical neurology and neurosurgery 2021-01, Vol.200, p.106348-106348, Article 106348
Main Authors: Pierscianek, Daniela, Ahmadipour, Yahya, Michel, Anna, Rauschenbach, Laurèl, Darkwah Oppong, Marvin, Deuschl, Cornelius, Kebir, Sied, Wrede, Karsten H., Glas, Martin, Stuschke, Martin, Sure, Ulrich, Jabbarli, Ramazan
Format: Article
Language:English
Subjects:
Age
Biopsy
Brain cancer
Cysts
Diagnosis
Genetic analysis
Glial fibrillary acidic protein
Glioblastoma
Gliosarcoma
Medical prognosis
Multivariate analysis
Mutation
Neurology
p53 Protein
Patients
Proteins
Software
Statistical analysis
Survival
Survival analysis
Temporal lobe
Tumor cysts
Tumors
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Summary:•Gliosarcoma show a temporal lobe predilection and eccentric tumor cysts.•Patients’ age, preoperative clinical status, midline tumor location and tumor size are prognostic factors in gliosarcoma.•Gliosarcoma are associated with a poorer outcome, this difference might be linked to different genetic alterations between gliosarcoma and glioblastoma. Gliosarcoma (GSC) is a rare histological variant of glioblastoma (GBM). Due to limited evidence regarding clinical, genetic and radiographic characteristics of GSC, this study aimed to analyze independent outcome predictors of GSC, and to address the differences between GSC and GBM concerning the baseline characteristics and patients’ survival. Patients treated between 2001 and 2018 for the diagnosis of GBM and GSC were included in this study. Patients’ records were reviewed for demographic, clinical, genetic and radiographic characteristics. Univariate, multivariate and propensity score matched analyses were performed. In the GSC sub-cohort (N = 56), patients’ age, preoperative clinical status, midline tumor location and tumor size were found to be independently associated with overall survival. As compared to GBM individuals (N = 1249), a temporal location (p = 0.002), presence of eccentric tumor cysts (p 
ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2020.106348