Accuracy of fine‐needle aspiration cytology in detecting cervical node metastasis after radiotherapy: Systematic review and meta‐analysis

Purpose To define the accuracy of fine‐needle aspiration cytology (FNAC) in diagnosing persistent or recurrent neck metastases in previously irradiated patients. Methods The study was performed according to the PRISMA‐DTA guidelines. Results A total of 382 FNACs were used for calculation of diagnost...

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Published in:Head & neck 2021-03, Vol.43 (3), p.987-996
Main Authors: Costantino, Andrea, Mercante, Giuseppe, D'Ascoli, Elisa, Ferreli, Fabio, Di Tommaso, Luca, Franzese, Ciro, Giannitto, Caterina, Casale, Manuele, Spriano, Giuseppe, De Virgilio, Armando
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Language:English
Subjects:
Accuracy
Cellular biology
Cytology
Head & neck cancer
Head and neck
head and neck cancer
Meta-analysis
Metastases
neck dissection
persistence
Radiation therapy
recurrence
salvage treatment
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container_end_page 996
container_issue 3
container_start_page 987
container_title Head & neck
container_volume 43
creator Costantino, Andrea
Mercante, Giuseppe
D'Ascoli, Elisa
Ferreli, Fabio
Di Tommaso, Luca
Franzese, Ciro
Giannitto, Caterina
Casale, Manuele
Spriano, Giuseppe
De Virgilio, Armando
description Purpose To define the accuracy of fine‐needle aspiration cytology (FNAC) in diagnosing persistent or recurrent neck metastases in previously irradiated patients. Methods The study was performed according to the PRISMA‐DTA guidelines. Results A total of 382 FNACs were used for calculation of diagnostic accuracy parameters. The overall pooled sensitivity and specificity in detecting malignant nodes were 69.1% (95% CI: 56.3%‐80.7%; I2 = 79.5%) and 84.2% (95% CI: 71.8%‐93.5%; I2 = 87.0%), respectively. Cumulative diagnostic odds ratio (DOR) was 16.54 (95% CI: 4.89‐38.99; I2 = 65.8%), while cumulative positive and negative likelihood ratio (PLR and NLR) were 5.4 (95% CI: 2.3‐11.2) and 0.37 (95% CI: 0.22‐0.54), respectively. Conclusions FNAC alone could not guide the decision to perform a salvage neck dissection in previously irradiated patients, but its results should be assessed in relation to the specific clinical context.
doi_str_mv 10.1002/hed.26536
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Methods The study was performed according to the PRISMA‐DTA guidelines. Results A total of 382 FNACs were used for calculation of diagnostic accuracy parameters. The overall pooled sensitivity and specificity in detecting malignant nodes were 69.1% (95% CI: 56.3%‐80.7%; I2 = 79.5%) and 84.2% (95% CI: 71.8%‐93.5%; I2 = 87.0%), respectively. Cumulative diagnostic odds ratio (DOR) was 16.54 (95% CI: 4.89‐38.99; I2 = 65.8%), while cumulative positive and negative likelihood ratio (PLR and NLR) were 5.4 (95% CI: 2.3‐11.2) and 0.37 (95% CI: 0.22‐0.54), respectively. Conclusions FNAC alone could not guide the decision to perform a salvage neck dissection in previously irradiated patients, but its results should be assessed in relation to the specific clinical context.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.26536</identifier><identifier>PMID: 33166002</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley &amp; Sons, Inc</publisher><subject>Accuracy ; Cellular biology ; Cytology ; Head &amp; neck cancer ; Head and neck ; head and neck cancer ; Meta-analysis ; Metastases ; neck dissection ; persistence ; Radiation therapy ; recurrence ; salvage treatment</subject><ispartof>Head &amp; neck, 2021-03, Vol.43 (3), p.987-996</ispartof><rights>2020 Wiley Periodicals LLC.</rights><rights>2021 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-1009-7892 ; 0000-0003-2066-9572 ; 0000-0001-6893-6284 ; 0000-0003-0738-8223 ; 0000-0001-5551-7785</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33166002$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Costantino, Andrea</creatorcontrib><creatorcontrib>Mercante, Giuseppe</creatorcontrib><creatorcontrib>D'Ascoli, Elisa</creatorcontrib><creatorcontrib>Ferreli, Fabio</creatorcontrib><creatorcontrib>Di Tommaso, Luca</creatorcontrib><creatorcontrib>Franzese, Ciro</creatorcontrib><creatorcontrib>Giannitto, Caterina</creatorcontrib><creatorcontrib>Casale, Manuele</creatorcontrib><creatorcontrib>Spriano, Giuseppe</creatorcontrib><creatorcontrib>De Virgilio, Armando</creatorcontrib><title>Accuracy of fine‐needle aspiration cytology in detecting cervical node metastasis after radiotherapy: Systematic review and meta‐analysis</title><title>Head &amp; neck</title><addtitle>Head Neck</addtitle><description>Purpose To define the accuracy of fine‐needle aspiration cytology (FNAC) in diagnosing persistent or recurrent neck metastases in previously irradiated patients. Methods The study was performed according to the PRISMA‐DTA guidelines. Results A total of 382 FNACs were used for calculation of diagnostic accuracy parameters. The overall pooled sensitivity and specificity in detecting malignant nodes were 69.1% (95% CI: 56.3%‐80.7%; I2 = 79.5%) and 84.2% (95% CI: 71.8%‐93.5%; I2 = 87.0%), respectively. Cumulative diagnostic odds ratio (DOR) was 16.54 (95% CI: 4.89‐38.99; I2 = 65.8%), while cumulative positive and negative likelihood ratio (PLR and NLR) were 5.4 (95% CI: 2.3‐11.2) and 0.37 (95% CI: 0.22‐0.54), respectively. 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neck cancer</topic><topic>Head and neck</topic><topic>head and neck cancer</topic><topic>Meta-analysis</topic><topic>Metastases</topic><topic>neck dissection</topic><topic>persistence</topic><topic>Radiation therapy</topic><topic>recurrence</topic><topic>salvage treatment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Costantino, Andrea</creatorcontrib><creatorcontrib>Mercante, Giuseppe</creatorcontrib><creatorcontrib>D'Ascoli, Elisa</creatorcontrib><creatorcontrib>Ferreli, Fabio</creatorcontrib><creatorcontrib>Di Tommaso, Luca</creatorcontrib><creatorcontrib>Franzese, Ciro</creatorcontrib><creatorcontrib>Giannitto, Caterina</creatorcontrib><creatorcontrib>Casale, Manuele</creatorcontrib><creatorcontrib>Spriano, Giuseppe</creatorcontrib><creatorcontrib>De Virgilio, Armando</creatorcontrib><collection>PubMed</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head &amp; neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Costantino, Andrea</au><au>Mercante, Giuseppe</au><au>D'Ascoli, Elisa</au><au>Ferreli, Fabio</au><au>Di Tommaso, Luca</au><au>Franzese, Ciro</au><au>Giannitto, Caterina</au><au>Casale, Manuele</au><au>Spriano, Giuseppe</au><au>De Virgilio, Armando</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Accuracy of fine‐needle aspiration cytology in detecting cervical node metastasis after radiotherapy: Systematic review and meta‐analysis</atitle><jtitle>Head &amp; neck</jtitle><addtitle>Head Neck</addtitle><date>2021-03</date><risdate>2021</risdate><volume>43</volume><issue>3</issue><spage>987</spage><epage>996</epage><pages>987-996</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Purpose To define the accuracy of fine‐needle aspiration cytology (FNAC) in diagnosing persistent or recurrent neck metastases in previously irradiated patients. Methods The study was performed according to the PRISMA‐DTA guidelines. Results A total of 382 FNACs were used for calculation of diagnostic accuracy parameters. The overall pooled sensitivity and specificity in detecting malignant nodes were 69.1% (95% CI: 56.3%‐80.7%; I2 = 79.5%) and 84.2% (95% CI: 71.8%‐93.5%; I2 = 87.0%), respectively. Cumulative diagnostic odds ratio (DOR) was 16.54 (95% CI: 4.89‐38.99; I2 = 65.8%), while cumulative positive and negative likelihood ratio (PLR and NLR) were 5.4 (95% CI: 2.3‐11.2) and 0.37 (95% CI: 0.22‐0.54), respectively. 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subjects Accuracy
Cellular biology
Cytology
Head & neck cancer
Head and neck
head and neck cancer
Meta-analysis
Metastases
neck dissection
persistence
Radiation therapy
recurrence
salvage treatment
title Accuracy of fine‐needle aspiration cytology in detecting cervical node metastasis after radiotherapy: Systematic review and meta‐analysis
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