An update: mechanisms of microRNA in primary open-angle glaucoma

Glaucoma is a disease with characteristic optic neuropathy and loss of vision, leading to blindness, and primary open-angle glaucoma (POAG) is the most common glaucoma type throughout the world. Genetic susceptibility is the main factor in POAG, and most susceptibility genes cause changes in microRN...

Full description

Saved in:
Bibliographic Details
Published in:Briefings in functional genomics 2021-03, Vol.20 (1), p.19-27
Main Authors: Wang, Yuanping, Niu, Lingzhi, Zhao, Jing, Wang, Mingxuan, Li, Ke, Zheng, Yajuan
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c291t-446d5cfa318981ae48d7b0f6e4ab5120fed04ad20b362b0740b6d782f20a865b3
cites cdi_FETCH-LOGICAL-c291t-446d5cfa318981ae48d7b0f6e4ab5120fed04ad20b362b0740b6d782f20a865b3
container_end_page 27
container_issue 1
container_start_page 19
container_title Briefings in functional genomics
container_volume 20
creator Wang, Yuanping
Niu, Lingzhi
Zhao, Jing
Wang, Mingxuan
Li, Ke
Zheng, Yajuan
description Glaucoma is a disease with characteristic optic neuropathy and loss of vision, leading to blindness, and primary open-angle glaucoma (POAG) is the most common glaucoma type throughout the world. Genetic susceptibility is the main factor in POAG, and most susceptibility genes cause changes in microRNA expression and function, thereby leading to POAG occurrence and development. Increasing evidence indicates that many microRNAs are involved in the regulation of intraocular pressure (IOP) and play an important role in the increase in IOP in POAG. Additionally, microRNA is closely related to optic nerve damage factors (mechanical stress, hypoxia and inflammation). This review discusses the effect of single-nucleotide polymorphisms in POAG-related genes on microRNA and the value of microRNA in the diagnosis and treatment of POAG.
doi_str_mv 10.1093/bfgp/elaa020
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2458959735</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2458959735</sourcerecordid><originalsourceid>FETCH-LOGICAL-c291t-446d5cfa318981ae48d7b0f6e4ab5120fed04ad20b362b0740b6d782f20a865b3</originalsourceid><addsrcrecordid>eNo9kE1Lw0AQhhdRbKm9eZY9ejB29jOJJ0vxC4qC6HmZTXZrJF9mk4P_3pTGzuWdw8PLzEPIJYNbBqlYWb9rV65EBA4nZM5BsohrFZ8ed5nOyDKEbxhHMCkZnJOZEEwrxfSc3K9rOrQ59u6OVi77wroIVaCNp1WRdc3765oWNW27osLulzatqyOsd6WjuxKHrKnwgpx5LINbTrkgn48PH5vnaPv29LJZb6OMp6yPpNS5yjwKlqQJQyeTPLbgtZNoFePgXQ4Scw5WaG4hlmB1Hifcc8BEKysW5PrQ23bNz-BCb6oiZK4ssXbNEAyXKklVGgs1ojcHdHwghM55M91vGJi9NrPXZiZtI341NQ-2cvkR_pck_gDlzmhe</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2458959735</pqid></control><display><type>article</type><title>An update: mechanisms of microRNA in primary open-angle glaucoma</title><source>Oxford Journals Online</source><creator>Wang, Yuanping ; Niu, Lingzhi ; Zhao, Jing ; Wang, Mingxuan ; Li, Ke ; Zheng, Yajuan</creator><creatorcontrib>Wang, Yuanping ; Niu, Lingzhi ; Zhao, Jing ; Wang, Mingxuan ; Li, Ke ; Zheng, Yajuan</creatorcontrib><description>Glaucoma is a disease with characteristic optic neuropathy and loss of vision, leading to blindness, and primary open-angle glaucoma (POAG) is the most common glaucoma type throughout the world. Genetic susceptibility is the main factor in POAG, and most susceptibility genes cause changes in microRNA expression and function, thereby leading to POAG occurrence and development. Increasing evidence indicates that many microRNAs are involved in the regulation of intraocular pressure (IOP) and play an important role in the increase in IOP in POAG. Additionally, microRNA is closely related to optic nerve damage factors (mechanical stress, hypoxia and inflammation). This review discusses the effect of single-nucleotide polymorphisms in POAG-related genes on microRNA and the value of microRNA in the diagnosis and treatment of POAG.</description><identifier>ISSN: 2041-2649</identifier><identifier>EISSN: 2041-2657</identifier><identifier>DOI: 10.1093/bfgp/elaa020</identifier><identifier>PMID: 33165516</identifier><language>eng</language><publisher>England</publisher><ispartof>Briefings in functional genomics, 2021-03, Vol.20 (1), p.19-27</ispartof><rights>The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c291t-446d5cfa318981ae48d7b0f6e4ab5120fed04ad20b362b0740b6d782f20a865b3</citedby><cites>FETCH-LOGICAL-c291t-446d5cfa318981ae48d7b0f6e4ab5120fed04ad20b362b0740b6d782f20a865b3</cites><orcidid>0000-0003-2327-3733</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33165516$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Yuanping</creatorcontrib><creatorcontrib>Niu, Lingzhi</creatorcontrib><creatorcontrib>Zhao, Jing</creatorcontrib><creatorcontrib>Wang, Mingxuan</creatorcontrib><creatorcontrib>Li, Ke</creatorcontrib><creatorcontrib>Zheng, Yajuan</creatorcontrib><title>An update: mechanisms of microRNA in primary open-angle glaucoma</title><title>Briefings in functional genomics</title><addtitle>Brief Funct Genomics</addtitle><description>Glaucoma is a disease with characteristic optic neuropathy and loss of vision, leading to blindness, and primary open-angle glaucoma (POAG) is the most common glaucoma type throughout the world. Genetic susceptibility is the main factor in POAG, and most susceptibility genes cause changes in microRNA expression and function, thereby leading to POAG occurrence and development. Increasing evidence indicates that many microRNAs are involved in the regulation of intraocular pressure (IOP) and play an important role in the increase in IOP in POAG. Additionally, microRNA is closely related to optic nerve damage factors (mechanical stress, hypoxia and inflammation). This review discusses the effect of single-nucleotide polymorphisms in POAG-related genes on microRNA and the value of microRNA in the diagnosis and treatment of POAG.</description><issn>2041-2649</issn><issn>2041-2657</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNo9kE1Lw0AQhhdRbKm9eZY9ejB29jOJJ0vxC4qC6HmZTXZrJF9mk4P_3pTGzuWdw8PLzEPIJYNbBqlYWb9rV65EBA4nZM5BsohrFZ8ed5nOyDKEbxhHMCkZnJOZEEwrxfSc3K9rOrQ59u6OVi77wroIVaCNp1WRdc3765oWNW27osLulzatqyOsd6WjuxKHrKnwgpx5LINbTrkgn48PH5vnaPv29LJZb6OMp6yPpNS5yjwKlqQJQyeTPLbgtZNoFePgXQ4Scw5WaG4hlmB1Hifcc8BEKysW5PrQ23bNz-BCb6oiZK4ssXbNEAyXKklVGgs1ojcHdHwghM55M91vGJi9NrPXZiZtI341NQ-2cvkR_pck_gDlzmhe</recordid><startdate>20210302</startdate><enddate>20210302</enddate><creator>Wang, Yuanping</creator><creator>Niu, Lingzhi</creator><creator>Zhao, Jing</creator><creator>Wang, Mingxuan</creator><creator>Li, Ke</creator><creator>Zheng, Yajuan</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2327-3733</orcidid></search><sort><creationdate>20210302</creationdate><title>An update: mechanisms of microRNA in primary open-angle glaucoma</title><author>Wang, Yuanping ; Niu, Lingzhi ; Zhao, Jing ; Wang, Mingxuan ; Li, Ke ; Zheng, Yajuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c291t-446d5cfa318981ae48d7b0f6e4ab5120fed04ad20b362b0740b6d782f20a865b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yuanping</creatorcontrib><creatorcontrib>Niu, Lingzhi</creatorcontrib><creatorcontrib>Zhao, Jing</creatorcontrib><creatorcontrib>Wang, Mingxuan</creatorcontrib><creatorcontrib>Li, Ke</creatorcontrib><creatorcontrib>Zheng, Yajuan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Briefings in functional genomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yuanping</au><au>Niu, Lingzhi</au><au>Zhao, Jing</au><au>Wang, Mingxuan</au><au>Li, Ke</au><au>Zheng, Yajuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An update: mechanisms of microRNA in primary open-angle glaucoma</atitle><jtitle>Briefings in functional genomics</jtitle><addtitle>Brief Funct Genomics</addtitle><date>2021-03-02</date><risdate>2021</risdate><volume>20</volume><issue>1</issue><spage>19</spage><epage>27</epage><pages>19-27</pages><issn>2041-2649</issn><eissn>2041-2657</eissn><abstract>Glaucoma is a disease with characteristic optic neuropathy and loss of vision, leading to blindness, and primary open-angle glaucoma (POAG) is the most common glaucoma type throughout the world. Genetic susceptibility is the main factor in POAG, and most susceptibility genes cause changes in microRNA expression and function, thereby leading to POAG occurrence and development. Increasing evidence indicates that many microRNAs are involved in the regulation of intraocular pressure (IOP) and play an important role in the increase in IOP in POAG. Additionally, microRNA is closely related to optic nerve damage factors (mechanical stress, hypoxia and inflammation). This review discusses the effect of single-nucleotide polymorphisms in POAG-related genes on microRNA and the value of microRNA in the diagnosis and treatment of POAG.</abstract><cop>England</cop><pmid>33165516</pmid><doi>10.1093/bfgp/elaa020</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-2327-3733</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 2041-2649
ispartof Briefings in functional genomics, 2021-03, Vol.20 (1), p.19-27
issn 2041-2649
2041-2657
language eng
recordid cdi_proquest_miscellaneous_2458959735
source Oxford Journals Online
title An update: mechanisms of microRNA in primary open-angle glaucoma
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T11%3A24%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=An%20update:%20mechanisms%20of%20microRNA%20in%20primary%20open-angle%20glaucoma&rft.jtitle=Briefings%20in%20functional%20genomics&rft.au=Wang,%20Yuanping&rft.date=2021-03-02&rft.volume=20&rft.issue=1&rft.spage=19&rft.epage=27&rft.pages=19-27&rft.issn=2041-2649&rft.eissn=2041-2657&rft_id=info:doi/10.1093/bfgp/elaa020&rft_dat=%3Cproquest_cross%3E2458959735%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c291t-446d5cfa318981ae48d7b0f6e4ab5120fed04ad20b362b0740b6d782f20a865b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2458959735&rft_id=info:pmid/33165516&rfr_iscdi=true