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Impact of the 13-valent pneumococcal conjugate vaccine (PCV13) on acute mastoiditis in children in southern Israel: A 12-year retrospective comparative study (2005–2016)
To define the trends in acute mastoiditis (AM) incidence, microbiology, complications and management in children, before and after the 13-valent pneumococcal conjugate vaccine (PVC13) introduction. Medical records of all AM patients
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Published in: | International journal of pediatric otorhinolaryngology 2021-01, Vol.140, p.110485-110485, Article 110485 |
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container_title | International journal of pediatric otorhinolaryngology |
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creator | Sapir, Aviad Ziv, Oren Leibovitz, Eugene Kordeluk, Sophia Rinott, Ehud El-Saied, Sabri Greenberg, David Kaplan, Daniel M. |
description | To define the trends in acute mastoiditis (AM) incidence, microbiology, complications and management in children, before and after the 13-valent pneumococcal conjugate vaccine (PVC13) introduction.
Medical records of all AM patients |
doi_str_mv | 10.1016/j.ijporl.2020.110485 |
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Medical records of all AM patients <15 years of age diagnosed during 2005–2016 were reviewed. The study years were divided into three periods: pre-vaccination (2005–2008), interim (2009–2011) and post-PCV13 vaccination (2012–2016).
238 patients (53.4% males) were enrolled, 81, 56 and 101 in the 3 time periods, respectively. Overall, 177/238 (75.2%) of children were <5 years of age. Mean AM incidence in the whole population was 10.32/100,000, with no changes during the study years. Ninety-three (45.6%) of 204 evaluable patients had positive middle ear fluid/mastoid cultures; S. pneumoniae (SP) was isolated in 47/93 (50.5%) cases. Mean incidence of SP-AM during the study years was 2.49 cases/100,000. A trend for decrease in mean incidence of SP-AM was recorded between the pre and the post-vaccination periods (3.05/100,000 vs. 1.82/100,000, P = 0.069). Among patients <5 years, SP-AM rates decreased from pre to post-vaccination period (19/50, 38% vs. 15/73, 20.6%, P = 0.034). No changes were reported in percentages of culture negative-AM and of AM complications in the post-PCV13 period compared with the pre-vaccine period. A significant decrease in distribution of PCV13 serotypes was recorded (17/19, 89.5% vs. 8/12, 66.6% and vs. 7/16, 43.75% during the 3 study periods, P = 0.015) accompanied by a complementary increase in non-vaccine serotypes.
The introduction of PCV13 was accompanied by a significant decrease in SP-AM cases among children <5 years of age. PCV13 serotypes decreased significantly as etiologic agents of SP-AM while non-vaccine serotypes and culture negative-AM became more common in the postvaccination period.</description><identifier>ISSN: 0165-5876</identifier><identifier>EISSN: 1872-8464</identifier><identifier>DOI: 10.1016/j.ijporl.2020.110485</identifier><identifier>PMID: 33168224</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Children ; Mastoiditis ; PCV13 ; Serotypes ; Streptococcus pneumoniae</subject><ispartof>International journal of pediatric otorhinolaryngology, 2021-01, Vol.140, p.110485-110485, Article 110485</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-3d801bae2996f238884144bfb1fcc0ed3064a2029acb0b0e1b6fd2cf76ec55013</citedby><cites>FETCH-LOGICAL-c362t-3d801bae2996f238884144bfb1fcc0ed3064a2029acb0b0e1b6fd2cf76ec55013</cites><orcidid>0000-0002-7446-1788</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33168224$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sapir, Aviad</creatorcontrib><creatorcontrib>Ziv, Oren</creatorcontrib><creatorcontrib>Leibovitz, Eugene</creatorcontrib><creatorcontrib>Kordeluk, Sophia</creatorcontrib><creatorcontrib>Rinott, Ehud</creatorcontrib><creatorcontrib>El-Saied, Sabri</creatorcontrib><creatorcontrib>Greenberg, David</creatorcontrib><creatorcontrib>Kaplan, Daniel M.</creatorcontrib><title>Impact of the 13-valent pneumococcal conjugate vaccine (PCV13) on acute mastoiditis in children in southern Israel: A 12-year retrospective comparative study (2005–2016)</title><title>International journal of pediatric otorhinolaryngology</title><addtitle>Int J Pediatr Otorhinolaryngol</addtitle><description>To define the trends in acute mastoiditis (AM) incidence, microbiology, complications and management in children, before and after the 13-valent pneumococcal conjugate vaccine (PVC13) introduction.
Medical records of all AM patients <15 years of age diagnosed during 2005–2016 were reviewed. The study years were divided into three periods: pre-vaccination (2005–2008), interim (2009–2011) and post-PCV13 vaccination (2012–2016).
238 patients (53.4% males) were enrolled, 81, 56 and 101 in the 3 time periods, respectively. Overall, 177/238 (75.2%) of children were <5 years of age. Mean AM incidence in the whole population was 10.32/100,000, with no changes during the study years. Ninety-three (45.6%) of 204 evaluable patients had positive middle ear fluid/mastoid cultures; S. pneumoniae (SP) was isolated in 47/93 (50.5%) cases. Mean incidence of SP-AM during the study years was 2.49 cases/100,000. A trend for decrease in mean incidence of SP-AM was recorded between the pre and the post-vaccination periods (3.05/100,000 vs. 1.82/100,000, P = 0.069). Among patients <5 years, SP-AM rates decreased from pre to post-vaccination period (19/50, 38% vs. 15/73, 20.6%, P = 0.034). No changes were reported in percentages of culture negative-AM and of AM complications in the post-PCV13 period compared with the pre-vaccine period. A significant decrease in distribution of PCV13 serotypes was recorded (17/19, 89.5% vs. 8/12, 66.6% and vs. 7/16, 43.75% during the 3 study periods, P = 0.015) accompanied by a complementary increase in non-vaccine serotypes.
The introduction of PCV13 was accompanied by a significant decrease in SP-AM cases among children <5 years of age. PCV13 serotypes decreased significantly as etiologic agents of SP-AM while non-vaccine serotypes and culture negative-AM became more common in the postvaccination period.</description><subject>Children</subject><subject>Mastoiditis</subject><subject>PCV13</subject><subject>Serotypes</subject><subject>Streptococcus pneumoniae</subject><issn>0165-5876</issn><issn>1872-8464</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kU2O1DAQhS0EYpqBGyDkZc8ijf-TZoE0agHT0kiwALaW41QYtxI72E5LvZs7cAxuxUlwk4ElK5fsV_X86kPoJSUbSqh6fdi4wxTisGGElStKRCMfoRVtalY1QonHaFVkspJNrS7Qs5QOhNCaSPkUXXBOVcOYWKGf-3EyNuPQ43wHmPLqaAbwGU8e5jHYYK0ZsA3-MH8zGfDRWOs84PWn3VfKr3Dw2Ni5PIwm5eA6l13CzmN754Yugj_XKcxldvR4n6KB4Q2-xpRVJzARR8gxpAlsdkcoNuUz0fypU567E14zQuSv-x-sRLl6jp70Zkjw4uG8RF_ev_u8u6luP37Y765vK8sVyxXvGkJbA2y7VT3jTdMIKkTbt7S3lkDHiRKmLG1rbEtaArRVfcdsXyuwUhLKL9F6mTvF8H2GlPXokoVhMB7CnDQTcstFXStZpGKR2hIjRej1FN1o4klTos-Y9EEvmPQZk14wlbZXDw5zO0L3r-kvlyJ4uwig5Dw6iDpZB95C52JZlu6C-7_Db5jspoE</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Sapir, Aviad</creator><creator>Ziv, Oren</creator><creator>Leibovitz, Eugene</creator><creator>Kordeluk, Sophia</creator><creator>Rinott, Ehud</creator><creator>El-Saied, Sabri</creator><creator>Greenberg, David</creator><creator>Kaplan, Daniel M.</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7446-1788</orcidid></search><sort><creationdate>202101</creationdate><title>Impact of the 13-valent pneumococcal conjugate vaccine (PCV13) on acute mastoiditis in children in southern Israel: A 12-year retrospective comparative study (2005–2016)</title><author>Sapir, Aviad ; Ziv, Oren ; Leibovitz, Eugene ; Kordeluk, Sophia ; Rinott, Ehud ; El-Saied, Sabri ; Greenberg, David ; Kaplan, Daniel M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-3d801bae2996f238884144bfb1fcc0ed3064a2029acb0b0e1b6fd2cf76ec55013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Children</topic><topic>Mastoiditis</topic><topic>PCV13</topic><topic>Serotypes</topic><topic>Streptococcus pneumoniae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sapir, Aviad</creatorcontrib><creatorcontrib>Ziv, Oren</creatorcontrib><creatorcontrib>Leibovitz, Eugene</creatorcontrib><creatorcontrib>Kordeluk, Sophia</creatorcontrib><creatorcontrib>Rinott, Ehud</creatorcontrib><creatorcontrib>El-Saied, Sabri</creatorcontrib><creatorcontrib>Greenberg, David</creatorcontrib><creatorcontrib>Kaplan, Daniel M.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pediatric otorhinolaryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sapir, Aviad</au><au>Ziv, Oren</au><au>Leibovitz, Eugene</au><au>Kordeluk, Sophia</au><au>Rinott, Ehud</au><au>El-Saied, Sabri</au><au>Greenberg, David</au><au>Kaplan, Daniel M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of the 13-valent pneumococcal conjugate vaccine (PCV13) on acute mastoiditis in children in southern Israel: A 12-year retrospective comparative study (2005–2016)</atitle><jtitle>International journal of pediatric otorhinolaryngology</jtitle><addtitle>Int J Pediatr Otorhinolaryngol</addtitle><date>2021-01</date><risdate>2021</risdate><volume>140</volume><spage>110485</spage><epage>110485</epage><pages>110485-110485</pages><artnum>110485</artnum><issn>0165-5876</issn><eissn>1872-8464</eissn><abstract>To define the trends in acute mastoiditis (AM) incidence, microbiology, complications and management in children, before and after the 13-valent pneumococcal conjugate vaccine (PVC13) introduction.
Medical records of all AM patients <15 years of age diagnosed during 2005–2016 were reviewed. The study years were divided into three periods: pre-vaccination (2005–2008), interim (2009–2011) and post-PCV13 vaccination (2012–2016).
238 patients (53.4% males) were enrolled, 81, 56 and 101 in the 3 time periods, respectively. Overall, 177/238 (75.2%) of children were <5 years of age. Mean AM incidence in the whole population was 10.32/100,000, with no changes during the study years. Ninety-three (45.6%) of 204 evaluable patients had positive middle ear fluid/mastoid cultures; S. pneumoniae (SP) was isolated in 47/93 (50.5%) cases. Mean incidence of SP-AM during the study years was 2.49 cases/100,000. A trend for decrease in mean incidence of SP-AM was recorded between the pre and the post-vaccination periods (3.05/100,000 vs. 1.82/100,000, P = 0.069). Among patients <5 years, SP-AM rates decreased from pre to post-vaccination period (19/50, 38% vs. 15/73, 20.6%, P = 0.034). No changes were reported in percentages of culture negative-AM and of AM complications in the post-PCV13 period compared with the pre-vaccine period. A significant decrease in distribution of PCV13 serotypes was recorded (17/19, 89.5% vs. 8/12, 66.6% and vs. 7/16, 43.75% during the 3 study periods, P = 0.015) accompanied by a complementary increase in non-vaccine serotypes.
The introduction of PCV13 was accompanied by a significant decrease in SP-AM cases among children <5 years of age. PCV13 serotypes decreased significantly as etiologic agents of SP-AM while non-vaccine serotypes and culture negative-AM became more common in the postvaccination period.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>33168224</pmid><doi>10.1016/j.ijporl.2020.110485</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-7446-1788</orcidid></addata></record> |
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subjects | Children Mastoiditis PCV13 Serotypes Streptococcus pneumoniae |
title | Impact of the 13-valent pneumococcal conjugate vaccine (PCV13) on acute mastoiditis in children in southern Israel: A 12-year retrospective comparative study (2005–2016) |
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