Lymphadenopathy in IgG4-related disease: a phenotype of severe activity and poor prognosis, with eotaxin-3 as a new biomarker

To clarify relevant proteins and clinical characteristics of a phenotype of IgG4-related disease (IgG4-RD) with lymphadenopathy. We enrolled patients newly diagnosed with IgG4-RD in our department between January 2000 and June 2018 and performed proteomic analysis to measure serum concentrations of...

Full description

Saved in:
Bibliographic Details
Published in:Rheumatology (Oxford, England) England), 2021-02, Vol.60 (2), p.967-975
Main Authors: Takanashi, Satoshi, Kikuchi, Jun, Sasaki, Takanori, Akiyama, Mitsuhiro, Yasuoka, Hidekata, Yoshimoto, Keiko, Seki, Noriyasu, Sugahara, Kunio, Chiba, Kenji, Kaneko, Yuko, Takeuchi, Tsutomu
Format: Article
Language:English
Subjects:
Biomarkers - blood
Chemokine CCL26 - blood
Correlation of Data
Eosinophilia - diagnosis
Eosinophilia - etiology
Female
Gene Expression Profiling - methods
Humans
Immunoglobulin G4-Related Disease - blood
Immunoglobulin G4-Related Disease - diagnosis
Immunoglobulin G4-Related Disease - physiopathology
Lymphadenopathy - diagnosis
Lymphadenopathy - etiology
Lymphadenopathy - immunology
Male
Middle Aged
Patient Acuity
Recurrence
Up-Regulation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To clarify relevant proteins and clinical characteristics of a phenotype of IgG4-related disease (IgG4-RD) with lymphadenopathy. We enrolled patients newly diagnosed with IgG4-RD in our department between January 2000 and June 2018 and performed proteomic analysis to measure serum concentrations of 1305 proteins. We extracted proteins overexpressed in patients with IgG4-RD with lymphadenopathy by comparing between those with lymphadenopathy, those without lymphadenopathy and healthy controls. We further reviewed all the patients with IgG4-RD in our institution and investigated the characteristics and prognosis of the patients with IgG4-RD with lymphadenopathy. Eighty-five patients with IgG4-RD were enrolled, of which, 55% had lymphadenopathy. Proteomic analysis in 31 patients with IgG4-RD and 6 healthy controls revealed that eotaxin-3 was a potential serum biomarker in the patients with lymphadenopathy versus those without lymphadenopathy and healthy controls. A cohort of 85 patients with IgG4-RD demonstrated that patients with lymphadenopathy showed a significantly higher serum IgG4, IgG4:IgG ratio, IgG4-RD responder index and eosinophilia (P 
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/keaa648