Mild and Selective Method of Bromination of Flavonoids

A new method was developed for the mild and selective bromination of simple aromatic compounds and flavonoids in good yields using α,β-dibromohydrocinnamic acid in the presence of a base. This procedure enables selective mono- or dibromination of compounds highly sensitive to oxidative or radical at...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2020-11, Vol.83 (11), p.3324-3331
Main Authors: Hurtová, Martina, Biedermann, David, Kuzma, Marek, Křen, Vladimír
Format: Article
Language:English
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Summary:A new method was developed for the mild and selective bromination of simple aromatic compounds and flavonoids in good yields using α,β-dibromohydrocinnamic acid in the presence of a base. This procedure enables selective mono- or dibromination of compounds highly sensitive to oxidative or radical attack. New brominated derivatives of silymarin flavonolignans and related flavonoids were prepared. These brominated derivatives can be used as valuable synthetic intermediates in further synthesis.
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.0c00655