Imaging of a retinal pigment epithelium aperture using polarization-sensitive optical coherence tomography

Purpose To evaluate cases with a retinal pigment epithelium (RPE) aperture using polarization-sensitive optical coherence tomography (PS-OCT). Study design Retrospective consecutive case series. Methods A retrospective study that included three eyes (three patients) with RPE aperture and age-related...

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Bibliographic Details
Published in:Japanese journal of ophthalmology 2021, Vol.65 (1), p.30-41
Main Authors: Obata, Ryo, Yoshinaga, Akie, Yamamoto, Motoshi, Komatsu, Kayoko, Aoki, Nobuyori, Yamanari, Masahiro, Sugiyama, Satoshi, Minami, Takahiro, Azuma, Keiko, Inoue, Tatsuya, Aihara, Makoto, Kato, Satoshi
Format: Article
Language:English
Subjects:
Age
Age related diseases
Apertures
Clinical Investigation
Depolarization
Discontinuity
Epithelium
Evaluation
Eye diseases
Macular degeneration
Medicine
Medicine & Public Health
Ophthalmology
Optical Coherence Tomography
Patients
Polarization
Reflectance
Retina
Retinal pigment epithelium
Sensitivity
Tomography
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Summary:Purpose To evaluate cases with a retinal pigment epithelium (RPE) aperture using polarization-sensitive optical coherence tomography (PS-OCT). Study design Retrospective consecutive case series. Methods A retrospective study that included three eyes (three patients) with RPE aperture and age-related macular degeneration (AMD) evaluated at the Macular Clinic in Tokyo University Hospital. A three-dimensional dataset of depolarization information was obtained with a clinical prototype of PS-OCT. Results All patients were categorized as intermediate AMD. RPE apertures were identified with PS-OCT as discontinuities of depolarization in the RPE layer of the pigment epithelial detachment (PED). A nonuniform decrease of depolarization in the RPE layer was also observed around the aperture. Two findings were observed above the aperture, intraretinal focal areas with high reflectivity and increased depolarization and subretinal bands with moderate reflectivity and low depolarization. Retinal sensitivity according to fundus microperimetry measured at 25 points was significantly associated with the degree of depolarization at the corresponding area (r-square = 0.60, p = 0.0001). Conclusion The RPE aperture was characterized as a round discontinuity of depolarization. The findings with PS-OCT suggest atrophic changes in the overlying RPE of the PED. The degree of depolarization was associated with retinal sensitivity. The current results indicate that RPE apertures developed within the spectrum of atrophic AMD.
ISSN:0021-5155
1613-2246
DOI:10.1007/s10384-020-00787-4