Immune‐mediated haemolytic anaemia and thrombocytopenia in 25 adult equids: 1997‐2016

Background Information concerning clinical presentation, conditions associated with immune‐mediated haemolytic anaemia (IMHA) and thrombocytopenia (IMTP) and outcome in equids is lacking. Previous case reports suggest that immune‐mediated disease and neoplasia are associated. Objectives Characterise...

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Bibliographic Details
Published in:Equine veterinary journal 2021-09, Vol.53 (5), p.964-971
Main Authors: Easton‐Jones, Charlotte A., Estell, Krista E., Magdesian, K. Gary
Format: Article
Language:English
Subjects:
Anemia
Disease
horse
IMHA
IMTP
neoplasia
outcome
Thrombocytopenia
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Summary:Background Information concerning clinical presentation, conditions associated with immune‐mediated haemolytic anaemia (IMHA) and thrombocytopenia (IMTP) and outcome in equids is lacking. Previous case reports suggest that immune‐mediated disease and neoplasia are associated. Objectives Characterise the clinical presentation, clinicopathologic data, underlying conditions, treatment and outcome of IMHA and IMTP cases in equids. We hypothesise that IMHA with concurrent thrombocytopenia occurs more often than IMHA or IMTP alone, and that neoplasia is commonly associated with these immune diseases and cases frequently have a poor prognosis. Study design Retrospective case‐control study. Methods Medical records were reviewed from 1997 to 2016. Twenty‐five equids were diagnosed with IMHA, IMTP or IMHA with thrombocytopenia by Coombs test or flow cytometry. Controls were equids presented for nonimmune‐mediated disease immediately prior to and after study animals. Fisher's exact test was used to compare between groups for categorical variables (P 
ISSN:0425-1644
2042-3306
DOI:10.1111/evj.13384